Graves' disease is a relatively rare disease. Much more common are latent forms of hyperthyroidism, various types, or rather degrees of Graves. Cases of an asthenic constitution with an easily excitable cardiovascular system, with a tendency to hyperglycemia and poor tolerance to carbohydrates, with phenomena of general erethism should require careful attention, especially on the part of pediatricians, since children with this kind of constitutional state are distinguished by instability of metabolism and weak resistance to infections in general and.

The so-called hypothyroid constitution is the opposite.. This is natural, since along with a complete loss of thyroid function, we constantly meet here its partial violations..

However, changes in connective tissue are characteristic common to all types of thyroid insufficiency: pastiness, a tendency to obesity, a reduced ability to chemical regeneration underlying atrophic conditions, and an increased hydrophilicity of its colloids, expressed to a greater or lesser extent, are never absent..

Pastosis of myxedematics, pasty and at the same time senile wrinkled, dry, atrophic skin of nerds are the most striking signs of connective tissue changes characteristic of hypothyroidism.

Hypothyroidists are characterized by extreme backwardness in growth (dwarf growth of nerds and congenital myxedematics) and characteristic external manifestations of a violation of the trophic functions of mesenchymal elements: brittle nails, hair loss, early formation of wrinkles.

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