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Mourinho's team scored a goal in each half.
Read the match report later on our website.
Tottenham 2-0 Brentford Goals: Sissoko, 12, Sleep, 70.
Tottenham: Lloris - Aurier, Sanchez, Dyer, Regilon (Davis, 71) - Sissoko, Hoybjerg (Tanganga, 86) - Moura (Winks, 71), Ndombele, Son Heung Min (Vinicius, 88) - Kane.
Brentford: Raya - Dalsgaard, Pinnock, Sorensen, Henry - Dasilva, Janelt (Marcondes, 74), Jensen - Mbemo (Forss, 81), Toney, Kanos (Fosu, 74).
Warnings: Regilon - Kanos, Yanelta, Mbemo.
Josh Dasilva (Brentford) was sent off in the 84th minute (foul).