8-year-old boy clears peanut allergy after undergoing bone marrow transplant to treat acute lymphocytic leukemia.

This is the first report of such a case in the US, although previously British researchers reported a similar cure for allergies in a 12-year-old patient..

This interesting approach, discovered by chance, is unlikely to be used in clinical practice for the treatment of peanut allergy, because the risks and costs of bone marrow transplantation are too high..

A unique case was presented at the annual meeting of the ACAAI (American College of Allergy, Asthma and Immunology) by Dr. Luo from North Shore LIJ Health System.

Analyzing this case will help scientists better understand how peanut allergy develops.. Dr. Luo noted that there have already been reports of " For example, a 71-year-old patient with pulmonary fibrosis previously received a lung from a 15-year-old donor who had a severe nut allergy..

After the transplant, the recipient had two episodes of anaphylaxis while eating desserts with nuts - only after that did he have to think about the "

There is also a report on a possible cure for HIV after stem cell transplantation.. A certain Timothy Brown received a stem cell transplant to treat leukemia.. Since the patient was HIV-positive, the doctors intentionally chose a donor who had a deficiency of CCR5 receptors in T-cells, that is, there was no main "

After the transplant, Brown showed no symptoms of HIV infection, and he was even able to stop antiretroviral drugs.. HIV researchers were impressed by this fact and immediately began looking for ways to replicate the success while avoiding expensive and risky transplants..

“The new report on an 8-year-old boy, like the case of curing HIV, is very interesting. But it's not being seen as a specific treatment for peanut allergy," Instead, the doctor proposes to study the mechanism of such treatment in more depth and find a way to modify the T-cells of patients with allergies..

The boy was initially diagnosed with a peanut allergy at the age of 15 months, when he had an acute reaction to peanut butter.. After a skin test, the doctors recommended avoiding peanuts and prescribed an automatic epinephrine syringe EpiPen for urgent cases..

In the future, the boy had no problems with allergies, but a few years later he was diagnosed with B-cell acute lymphocytic leukemia.. Chemotherapy helped keep the disease in remission for 4 years, but then he had to have a stem cell transplant. The donor was unrelated, the match was “good”, the donor had no history of allergies.

The following year, according to Dr. Luo, the ImmunoCap test did not detect IgE in the boy's blood, indicating an allergy to peanuts, although four years earlier, the level of immunoglobulin was 0.87. A year later, a skin test with peanuts was negative - the boy overcame allergies.

Of course, there may be other explanations for this phenomenon, but Dr. Luo and his colleagues are confident that it was the transplant that cured the allergy..

But there are other opinions. Dr.

Karen Freedle from Children's Hospital of Atlanta is skeptical about these data.. She says it would be much more reliable if the researchers could test the boy's immunoglobulin levels shortly after the transplant, rather than a year after..

Both Dr. Freedle and Dr. Dowling note that they themselves have seen cases where transplantation led to the " In this regard, Dr. Freedle says that doctors should definitely ask patients and donors about the presence of allergies..

medbe. en.