Experts argue that certain hours of taking medications affect the effectiveness of their effects on the body and the effectiveness of treatment. Scientists at the University of Pennsylvania have been able to identify in the brain a unique mechanism that regulates the susceptibility of the blood-brain barrier, depending on the time of day.

The blood-brain barrier (GEB) protects the brain's nervous tissue from penetration of toxins, antibodies, neurotransmitters and leukocytes, providing favorable conditions for its normal functioning. Together with foreign microorganisms, the BBB does not allow drugs to enter the body, which makes it very difficult to conduct therapeutic actions to combat diseases of the central nervous system.

The authors of the article, published in the profile publication Cell, described in it the experiments carried out by them, during which a greater permeability of the analogue of the GEB of fruit flies in the night period. Insects with a model of epilepsy were given appropriate medications, and those taking medication at night were more quickly cured after seizures.

Investigating the mechanism providing this regulation, the specialists managed to find out that in the dark time the passage of magnesium through the barrier formed by the cell compounds is much more active than in the daytime. The content of matter in the cells themselves is reduced, and this facilitates its easy penetration into the brain.

The found mechanism that influences the susceptibility of the organism to medications will help correctly calculate the hours of taking medications and improve the quality of treatment for patients with serious CNS diseases.

medinfo. ua.

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