Scientists at Michigan State University are testing a new drug, codenamed I-BET-762, that could stop the c-Myc gene linked to obesity.. The same gene is associated with an increased risk of breast and lung cancer.. Blocking the expression of this gene occurs due to inhibition of the activity of a whole set of proteins in both immune and cancer cells..
In particular, the pSTAT3 protein can be activated in immune cells: this will block the work of these cells and the cancer will easily spread throughout the body.. This protein is also secreted in high concentrations in cancer cells, acting as a tumor-saving protective barrier..
Experiments with mice showed that I-BET-762 reduced the number of cancer cells by 80% by reducing the level of pSTAT3 by 50% in cancer and immune cells at the same time..
It was also found that the tool does not allow more than 50% of cells in a precancerous state to become cancerous.. It is known that the c-Myc gene is associated with visceral fat, which accumulates around the internal organs and is much more dangerous than subcutaneous fat.. Therefore, according to scientists, it is not surprising that cancer and internal obesity are linked..
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