The hormone DHEA C (dehydroepiandrosterone sulfate, DHEAS) is a weak androgen, one of the male sex hormones.. It is determined in the blood of both men and women, but in different amounts. The main site of synthesis is the adrenal glands (cortex). The substance is also produced in the ovaries / testicles, but not more than 3-5% of the norm. It has a circadian (daily) type of production, that is, the maximum amount of it is found in the blood in the morning.
Dehydroepiandrosterone sulfate is a steroid, one of the male sex hormones, which is also produced in the body of women. Main functions The DHEAS hormone is responsible for the following functions in the body:.
It is a precursor hormone from which the main male (testosterone) and female (estrogen) sex hormones are subsequently formed..
Participates in the formation of secondary sexual characteristics (hair growth, deposition of adipose tissue, changes in voice and external genitalia).
Stimulates estrogen production in the placenta during pregnancy.
Regulates sex drive.
Reduces blood cholesterol levels.
Changes the biochemical structure of the brain (affects mood and general well-being).
It has the opposite effect of cortisol, the stress hormone. Accordingly, its increase in the blood provides a way out of stressful conditions..
Regulates the cardiovascular system (increases vascular tone).
Regulates the functions of the immune system (partial effect). There is evidence of the ability of this substance to prevent the development and division of cancer cells (or slow down).
10. Partially stimulates the pituitary gland in the brain and stimulates the production of ACTH (regulates the work of all adrenal glands).
eleven. Slows down the aging process (anti-aging function).
The effect of this androgen on the body is less pronounced than that of other steroid hormones..
The concentration of the hormone DHEA C is of particular importance in pregnant women. Its increase can provoke spontaneous abortion..
Norm in womenThe norm of DHEA sulfate in women will depend on several indicators:.
age;
cycle time;
pregnancy.
In men, in the absence of concomitant diseases (Itsenko-Cushing syndrome), the indicator of values \u200b\u200bdoes not change.
Analysis is best done in the middle of the cycle (10-12th day).
Age.
Lower limit (µmol/l).
Upper limit (µmol/l).
Up to 5 years.
Has no diagnostic value From 5 to 10 years.
0.25.
1.6.
From 10 to 15 years (puberty, the establishment of the menstrual cycle).
1.0.
9.2.
15 to 30 (puberty).
2.5.
14.5.
From 30 to 50 (the period of extinction of sexual functions).
1.8.
10.0.
Over 50 (onset of menopause).
0.95.
3.4.
Over 60 (prolonged menopause).
0.08.
3.6.
*Dehydroepiandrosterone readings will depend on specific reagents. Blood testing systems may vary from laboratory to laboratory. Therefore, if it is necessary to repeat the study, it is better to conduct it in the same laboratory..
Indicators can also be presented in mcg / dl:.
Age.
Values \u200b\u200bfrom (mcg/dl).
Values \u200b\u200bup to (mcg/dl).
Up to 5 years.
Has no diagnostic value From 5 to 10 years.
2.7.
86.0.
From 10 to 15 years (puberty, the establishment of the menstrual cycle).
33.0.
280.0.
15 to 20 (puberty).
65.0.
370.0.
21 to 25 (puberty).
149.0.
408.0.
26 to 35 (puberty).
100.0.
340.0.
From 36 to 44 (the period of extinction of sexual functions).
60.0.
340.0.
44 to 55 (menopause).
36.0.
250.0.
Over 55 (onset of menopause).
19.0.
200.0.
Over 60 (prolonged menopause).
10.0.
155.0.
The concentration of the hormone DHEA C is of particular importance in pregnant women. Its increase can provoke spontaneous abortion..
Term.
Values \u200b\u200bfrom (µmol/l).
Values \u200b\u200bup to (µmol/l).
First trimester.
3.13.
12.5.
Second trimester.
1.8.
7.2.
last trimester.
0.9.
3.5.
The blood test is carried out using immunochemiluminescent analysis. For research use blood serum (from a vein). In the first year of life, the level is very high, stabilizing by 3-4 years. In youth, the necessary amount of hormones is produced in the body and does not require additional introduction from the outside..
Indications for analysis:.
adrenal gland test (suspicion for a tumor);
infertility or as preparation for IVF;
other gynecological diseases (cyst, amenorrhea);
diseases of the endocrine system (precocious puberty, hirsutism);
suspected miscarriage (pain, spotting in early pregnancy).
The analysis is carried out as an addition to the main diagnostic schemes (for each individual disease). Can serve for the differential diagnosis of precocious puberty (pathological and physiological).
Causes of an increase in DHEA C There are the following reasons for an increase in the hormone in the blood:.
Itsenko-Cushing's disease and syndrome.
Suspicion of placental abruption or placental insufficiency. During pregnancy, the placenta is an organ that stimulates the production of DHEA C and subsequently controls estrogens..
Any malignant or benign diseases of the abdominal cavity and retroperitoneal space (kidneys, intestines).
Diseases of the pelvic organs - ovaries, bladder. Simultaneous mechanical compression and hormonal disturbance.
Adrenogenital syndrome - a disease associated with a violation of the synthesizing function of the adrenal glands (a significant increase in male sex hormones in the blood).
Factors affecting blood levels (both increase and decrease):.
reduced immunity and autoimmune reactions;
chronic sources of infection and prolonged lack of treatment;
hereditary predisposition (defect in the gene encoding the synthesis of DHEA C);
taking hormonal drugs;
physical and emotional stress (overwork, stress);
smoking, alcohol abuse.
Symptoms will depend on the specific cause of the condition.. Depending on this, the doctor prescribes the appropriate course of treatment.. Experts for advice:.
gynecologist;
endocrinologist;
oncologist/oncosurgeon;
general surgeon (for suspected bowel tumor).
If a disease is detected, a long course of therapy is indicated (in severe cases, lifelong).
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