Cancer metastases are triggered by aging Cancer cells spread beyond the original tumor or metastases may be associated with aging. This conclusion was made by scientists from Johns Hopkins University..

Many patients with advanced malignant tumors experience a process of metastasis, where cancer cells separate from the original tumor and travel to other parts of the body, invading various tissues such as the lymph nodes, liver, kidneys, lungs, and the like.. As a rule, the process of metastasis is long and requires several years or even decades.. However, understanding of all these mechanisms has so far been incomplete.. And now a new lab study has shown that age-related changes in parts of the body like the lungs can activate dormant cancer cells and encourage them to grow..

Researchers have found that age-related changes in secreted factors from lung fibroblasts - normal, benign cells in close proximity to tumors - facilitate the growth of dormant melanoma cells..

And age and changes in the skin microenvironment inhibit the growth of melanoma cells and lead to their dissemination, causing spread to distant organs, that is, metastasis..

Aging may play an important role in the development of cancer metastases. The study showed that if melanoma cells were injected into the skin of young and elderly mice, they moved to the lungs at the same rate, but in the body of older mice they grew much faster and formed larger tumors, and in the lungs of young mice remained in the form of small unicellular or.

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