Until recently, scientists did not know that the human bone marrow could be part of the endocrine system, according to Pannochka, an online publication for girls and women aged 14 to 35.. net New study shows bone marrow fat produces a little-studied hormone that affects metabolism and may reduce the risk of diseases like diabetes.

In the scientific journal Cell Metabolism, researchers from the University of Michigan (U-M) reported that adipose tissue in the bone marrow produces the hormone adiponectin, which helps the body break down fat and maintain insulin sensitivity..

The hormone adiponectin has also been linked to a reduced risk of diseases associated with obesity – certain types of cancer, type 2 diabetes, cardiovascular disease, and others..

Early representations of scientists.

Previous research has shown that high amounts of bone marrow fat are associated with negative health outcomes such as decreased bone mass, increased risk of fractures and osteoporosis.. But in a new study, when researchers looked at the role of this tissue in cancer patients receiving chemotherapy, it was found to be beneficial under certain conditions..

Study lead author Ormond MacDougald, a professor of medicine at the University of Michigan, says the findings are important because bone marrow adipose tissue “may play a positive, protective role, influencing adaptive functions outside of bone, at least when limited.

“We know that low levels of adiponectin are correlated with a variety of problems.. Our results suggest that bone marrow adipose tissue is a potential source of this hormone, and possibly other hormones that we have not yet discovered,” explains study co-author Dr. Erica Scheller, PhD student of Prof. McDougald..

Scientists already know that adiponectin is secreted by white adipose tissue, the same tissue that most Americans complain about in excess.. This hormone plays an important role in maintaining the sensitivity of cells to insulin.. High levels of adiponectin may reduce the risk of diabetes and cardiovascular disease.

Paradox: more fat - less adiponectin.

Then why are obese people more likely to suffer from cardiovascular disease and diabetes? If they have an excess of adipose tissue, then the level of adiponectin, it would seem, should go off scale. It is a paradox, but with the loss of adipose tissue, the level of adiponectin in the human body increases. Obese people have the lowest levels of adiponectin.

For some time, this was very embarrassing for researchers.. But the Michigan team still found the answer: it turned out that scientists were misled by an elementary lack of knowledge about the adipose tissue present in our body..

A new study shows that bone marrow adipose tissue, which increases with weight loss, is one of the main sources of adiponectin in the body during calorie restriction..

Through their work, the team demonstrated that bone marrow fat increases in people with anorexia and in patients who receive chemotherapy and radiation for ovarian and endometrial cancer..

When scientists blocked the formation of adipose tissue in diet-restricted mice, it led to a decrease in adiponectin levels, despite the fact that the formation of white adipose tissue remained unaffected.. This proves that bone marrow adipose tissue is an important source of adiponectin..

Study co-author Dr. William Cawthorn of McDougald's lab concluded: " This gave us insight into the mechanisms involved in circulating adiponectin levels.. There is a lot of additional work to be done to better understand these things and their applicability.”.

medbe. en.