Civilians and military may be exposed to organophosphates, which are found both in various pesticides and in chemical warfare weapons (like Sarin gas or Vx).

These substances cause damage to the nervous system of humans and other mammals, according to the online publication for girls and women from 14 to 35 years old Pannochka. net Now scientists are close to stabilizing a protein that can neutralize these potentially lethal substances and protect the brain..

A team of researchers led by Professors Jim Kim Montclare and Richard Bonneau of New York University published their findings in the journal ChemBioChem.. The work was aimed at finding ways to protect humans from organophosphorus substances..

The scientists looked at a group of proteins known as phosphodiesterases that can break down organophosphates.. The principle of the poisoning action of organophosphates is based on the fact that they bind the neurotransmitters necessary for the transmission of signals from one nerve cell to another.. This disrupts the proper functioning of the nervous system and can lead to permanent disorders in the central nervous system..

Previous research shows that even low doses of organophosphates can permanently damage the nervous system.. In a 2012 study, Dr Mackenzie Ross of University College London noted that most studies over the past 20 years have found an association between organophosphate exposure and cognitive impairment..

“Organophosphates pose a colossal threat to humans and wildlife. Unfortunately, it is not uncommon for humans to come into contact with these substances, both through accidental exposure to pesticides and through deliberate chemical attack,” Professor Montclair wrote..

She adds that scientists have known about the properties of phosphodiesterases for a long time, but before these substances "

In particular, these proteins had a very limited lifespan and low stability at high temperatures.. But the team applied molecular engineering and computational biology techniques to create new, highly stable structures suitable for clinical use..

Professor Montclair and her collaborators used the Rosetta computer simulation software to find vulnerabilities in the fluorinated phosphodiesterase molecule..

As a result of this approach, they managed to create a thermostable protein with a longer life span.. This protein completely retained its antidote properties, but was much more stable and practical..

All this allows the use of a new protein to prevent damage to the nervous system at the beginning of a gas attack or in case of accidental exposure to pesticides.. Professor Montclair's team, which received a patent for a new invention, plans to begin developing a therapeutic agent based on their substance..

neboleem. net.