1 in 5 people experience fatigue. This is a complex of symptoms for which character, weakness, lethargy, a sense of physical and mental discomfort. As a result, the quality of life decreases, a person loses interest in what is happening, working capacity decreases and conflicts appear in the family.. Sometimes these signs are attributed to overwork at work.. However, the reasons may be much broader..

Why fatigue occurs? If, despite proper rest and an 8-hour night's sleep, you still feel tired and overwhelmed, then most likely the fatigue is pathological.. The main reasons that lead to this condition are as follows:.

past viral and bacterial infections;

neurasthenia is an independent neurological disease;

burnout syndrome;

deficiency of the immune system;

disorders of the endocrine system.

Hypofunction of the thyroid gland and iodine deficiency as the causes of fatigue The thyroid gland controls almost all processes occurring in the human body. Its activity determines the usefulness and correctness of metabolism, the functional state of the nervous system and literally the work of each cell.. If there is little thyroid hormone produced (this condition is called hypothyroidism), then the metabolic rate decreases, the transmission of nerve impulses slows down, and the body goes into “inhibition” mode.

One of the main reasons for the decrease in the functional activity of the thyroid gland and the resulting fatigue and increased fatigue is iodine deficiency.. The body of a healthy person contains about 20 mg of this trace element, of which 80% is in the thyroid gland..

Iodine enters a person with food and is easily absorbed in the gastrointestinal tract, then entering the extracellular space.. From the blood, this mineral easily penetrates into various organs and tissues, and a significant part is selectively absorbed by the thyroid gland..

About 75 micrograms of iodine is used daily for the synthesis of thyroid hormones - thyroxine and triiodothyronine.. Thyroxine is predominantly produced in the thyroid gland.. In other tissues and organs, under the action of the tyrosinase enzyme, 1 atom of iodine is split off, which leads to the formation of trioidthyronine, which exhibits the greatest biological activity.. However, if there is little iodine intake, or the process of hormone synthesis is disturbed, the whole organism begins to suffer, and fatigue appears, which may be the first sign of thyroid hypofunction..

By the way, the reserves of thyroxine and triiodothyronine in the thyroid gland itself are only enough for 1 month to maintain the normal life support of the body.. If this endocrine organ is not helped in time, severe hypofunction may gradually occur..

Causes of HypothyroidismHypothyroidism can be caused by severe iodine deficiency.. The main sources of this trace element are the products of the oceans.. The highest concentration is found in seaweed, scallops, trepangs, fish oil. Vegetables, fruits, cereals do not have the ability to accumulate this mineral, as representatives of marine flora and fauna do, so the iodine content in them completely depends on the microelement composition of the soil. And for the formation of the required amount of hormones, a sufficient intake of iodine in the body is required.. If this does not happen, then first a hidden deficiency occurs, and then a clinically obvious one..

In addition to dietary features, reduced thyroid function may be the result of damage to its cells that synthesize thyroid hormones.. This mechanism is observed in autoimmune thyroiditis, exposure to drugs and toxic substances that adversely affect the endocrine system.. And modern life is full of such aggressive factors - smoking, poor ecology, poor nutrition, and constant psycho-emotional stress that can easily lead to hypofunction syndrome..

Peripheral hypothyroidism may be the result of insensitivity of cellular receptors to circulating thyroid hormones in the blood or the result of their inactivation.. This form accounts for only 5% of all cases of hypofunctional thyroid conditions..

Symptoms of an underactive thyroid Underactive syndrome with fatigue and other symptoms can occur at any age. Women are more susceptible to this condition, especially during the period of hormonal changes - the formation of the functional activity of the reproductive system, pregnancy and childbirth, the extinction of ovarian function (menopause).

It should be noted that the symptoms of hypothyroidism are nonspecific.. In addition to increased fatigue and muscle weakness, it is important to pay attention to other signs that indicate thyroid hypofunction.. It can be:.

feeling of constant chilliness;

drowsiness;

weight gain, even with a low-calorie diet;

decreased memory and concentration;

swelling of the face, hands and sometimes the entire subcutaneous fat;

dry skin;

increased peeling of elbows, knees, heels;

hair loss and dull appearance;

thinning of the outer edge of the eyebrows due to increased hair loss;

brittle nails;

decreased sex drive, men can sometimes have erectile dysfunction;

changing the timbre of the voice to a lower and more rough;

slow speech;

hearing loss.

Of course, these symptoms can also be associated with other diseases.. Therefore, laboratory diagnostics helps to understand the situation.. Screening examination involves the determination of thyroid-stimulating hormone (TSH) in the blood. This substance is normally produced by the pituitary gland and is a stimulant for the thyroid gland, causing it to increase the production of thyroid hormones.. The concentration of TSH increases when the level of thyroxine and triiodothyronine in the blood decreases, and vice versa, it decreases when these hormones become too much. Therefore, the main laboratory criterion for thyroid hypofunction is the rise in the level of TSH above the reference values.. For comparison, with hyperthyroidism, there is a decrease.

Drug treatment of hypofunction of the thyroid glandHypofunction of the thyroid gland necessarily needs correction. This is due to the fact that against the background of hypothyroidism, the likelihood of developing serious diseases, primarily atherosclerosis and myocardial infarction, increases.. Reproductive health also suffers. Patients with thyroid hypofunction may develop infertility, menstrual irregularities, uterine bleeding, polycystic ovaries and other gynecological pathologies.. Therefore, it is so important to help the thyroid gland in time and start causative treatment..

The generally accepted method of treating hypofunction is replacement therapy with thyroid hormone preparations that contain thyroxine.. The optimal daily dosage, which the endocrinologist selects individually for each patient, is taken 1 time per day, about half an hour before breakfast. The effectiveness of such treatment is assessed by the content of TSH in the blood..

Preparations for hypofunction of the thyroid gland In addition to levothyroxine (a natural analogue of thyroxine), peptide bioregulators can be used in the complex restoration of the functional state of the thyroid gland. This is a new direction in medicine, which pursues the goal of normalizing physiological processes that are disturbed as a result of the damaging effects of internal or external factors..

The ability of the cells of the human body to function normally and recover depends primarily on the protein composition, as well as vitamins and microelements.. Proteins are synthesized from amino acids. But 8 amino acids are indispensable, that is, under no circumstances are they formed in the body, but must be brought in from the outside.. Therefore, against the background of their deficiency, normal processes may be disrupted, that is, a failure of self-regulation develops..

Self-regulation of thyroid cellsProteins are not only the basis of the cell, they are also the basis of intercellular interaction. In 1999 Gunter Blobel showed that the protein molecule regulates itself. He was awarded the Nobel Prize for this discovery.. A transport code is encrypted in the structure of this molecule, which determines where a particular protein should be located and to which organ it is most important.. When these bioregulatory processes fail, the risks of developing functional and organic diseases often increase..

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