An international team of researchers from the USA, Japan and Switzerland has found that mast cells (mast cells), which are involved in the development of allergic reactions, also have a “bright” side - they can activate the production of regulatory T cells that suppress allergic inflammation..

This discovery may be the key to the development of fundamentally new methods of treating allergies..

In essence, what the researchers found is a previously unknown “stop tap” that nature provided for stopping an overreaction of the immune system..

If you create a substance that will start this process, allergies can be quickly brought under control..

For most allergy sufferers, taking antihistamines is a must..

Their immune system "

Until now, it has not been possible to "

Scientists from Stanford University, the Swiss Institute of Allergy and Asthma (SIAF), the University of Tokyo and the RIKEN Research Institute in Yokohama have discovered a unique mechanism.

Mast cells, or mast cells, in response to an allergen (for example, pollen) release a large amount of substances that initiate an inflammatory process..

But they also secrete a substance called interleukin-2, which induces the production of regulatory T cells (Treg) that suppress this process..

Scientists already know that regulatory T cells can suppress inflammation. For example, Treg injections prevent the development of autoimmune diseases in mice..

But for such treatment, it is necessary to inject a large number of regulatory T cells each time, which is not so easy to do in practice.. There are very few of them in the blood, and it is difficult and expensive to grow them in a test tube with current technologies..

Scientists now hope to teach human mast cells to work in the right direction by forcing them to produce regulatory T cells in the laboratory quickly and in sufficient quantities.. This could really revolutionize the treatment of allergic diseases..

medbe. en.