Hormones, or rather hormonal disorders, can play a major role in the development of some tumors - the classic example is prostate and breast cancer.. And scientists from the USA believe that intestinal cancer can be caused by an imbalance of hormones..

In addition to hormones, so to speak, of general action, affecting the functions of the whole organism or several of its systems (such substances include, for example, sex hormones), there are also hormones of a narrower focus and local action.

Among such hormonal substances, a special role belongs to guaniline, which is produced by cells of the intestinal mucosa and acts exclusively on them.. This hormone ensures the normal division of mucosal cells, which, unlike the cells of most other tissues of the body, divide at an increased rate..

Scientists from the Thomas Jefferson University in Philadelphia, America (Thomas Jefferson University in Philadelphia) examined tissue samples of malignant tumors from more than 280 patients with intestinal cancer, and compared the properties of tumor cells with cells of healthy intestinal tissues obtained from the same patients..

The researchers found that the secretion of the hormone guaniline by tumor cells was 100-1000 times less than in healthy cells, and this phenomenon was observed in 85% of patients..

In addition, scientists have found that after reaching the age of 50, a sharp decrease in guaniline secretion is also observed in healthy cells of the intestinal mucosa..

Based on these two discoveries, Philadelphia scientists hypothesized that age-related decline in guaniline secretion could disrupt the normal process of intestinal cell division..

The cells of the intestinal mucosa, as it was said, are renewed very quickly - every 3 days - for this reason, the absence of a corrective hormonal signal can cause their abnormal division and degeneration into cancerous.

Now scientists from the University of Thomas Jefferson have to find out if the introduction of guaniline (a kind of hormone replacement therapy) can reduce the risk of degeneration of noreal intestinal cells into cancerous cells..

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