Brugsch and Michaelis hypothesized that there are special centers that control the secretion of uric acid.. According to Michaelis, Dresel et al.. , " Levy joins this opinion, and Humbert builds on this his hypothesis about the vegetative-nervous origin of gout..

If, however, we take into account that the increased excretion of uric acid depends on the " from conditions completely analogous to those when, depending on the content of glycogen in the liver, a sugar injection causes or does not.

gives hyperglycemia and glycosuria, it will become quite clear that in special cases experimenters act not on non-existent centers of "

A brief analysis of the data on the vegetative exchange centers, specific in their chemical sensitivity, leads us to the conclusion that the centers with such sensitivity, apparently, do not exist.. There are a number of anatomical and physiological centers of various organs and centers of combined reflexes between them..

The question naturally arises as to how the autonomic nervous system exerts its influence on the function of the organ..

First of all, vasomotor influences should be named here as not causing any doubts.. The working organ reflexively causes a rush of blood and an increase in blood circulation by reflex inhibition of vasoconstrictor effects on the precapillary arterioles. Arterial hyperemia is equally a consequence and stimulus of increased organ work.

Along with this, apparently, every cell of the body that has an active metabolism receives sympathetic innervation. The role of these nerves is determined by the concept of secretory and trophic influences. The essence of these influences, it seems to me, is the same: excitement or lack thereof. It is hardly necessary to distinguish secretory nerves, for example, from those supporting muscle tone..

The difference in final effects is determined rather by the physiological characteristics of various cells than by the difference in the influences of sympathetic nerves.. Trophic phenomena are the result of metabolism in cells, the tone of which is maintained by nerve impulses.

The physicochemical nature of these impulses is still far from clear.. Ionic theory of excitation, the idea of \u200b\u200bwhich science owes to P. Lazarev, in its further development will undoubtedly shed light on one of the most interesting pages of biology.

Part 1.

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