The neuro-endocrine theory of thermoregulation and the pathogenesis of fever is thus just as dubious as the existence of a separate specific thermal nerve center is dubious.. The denial of this theory does not mean, of course, either a denial of the influence of autonomic nerve centers on the occurrence and course of fever, or a denial of the influence of the endocrine glands on metabolic processes.. On the contrary, here, in order to avoid misunderstandings, we would like to especially emphasize the enormous importance of the state of the autonomic nervous system in the body's fight against infection, which spreads its influence, however, not only on the thermoregulation of the body, but decisively on all its functions..

Recognition of a specific localized thermoregulatory center requires logically recognition of it simultaneously as the highest center of all types of exchange with which heat production is associated, and at the same time as the center and all those devices by means of which heat transfer is regulated in the body.. Such recognition creates, however, insurmountable difficulties for the very supporters of the existence of chemical sensitivity in nerve centers..

Undoubtedly, all types of metabolism, as they appear to modern biochemistry, undergo disruption under the influence of a febrigenous agent on the body. As Manassein pointed out, under the influence of fever, liver glycogen disappears. Loss of the subcutaneous fat layer, emaciation of a febrile patient indicate increased fat breakdown. The increased " This protein breakdown is not caused by the need of a feverish body for calories, since it cannot be brought to normal by prescribing to the patient an abundant carbohydrate and fat diet.. There are always disorders of water and salt metabolism. Oxidative processes increase, according to Krel, by 20-30%.

in young people at the onset of the disease - up to 60%.

Despite this, there is an abundance of under-oxidized metabolic products in the urine. Is it possible to agree with the defenders of the hypothesis about a specific thermoregulatory center, whose cells themselves are not even able to distinguish the blood temperature and require messages for this from the cells of another center, which plays the role of a cerebral hermetic meter, that all these metabolic disorders are solely the result of a violation of its function

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