Hyperaldosteronism - a pathological syndrome in which excessive production of aldosterone is diagnosed by the glomerular zone of the adrenal cortex.

Aldosterone is a mineralocorticosteroid, a hormone responsible for maintaining sodium-potassium balance in the body. Its increased secretion leads to metabolic disorders.

In women, primary hyperaldosteronism is recorded 3 times more often, manifestation occurs after 30 years.

Primary hyperaldosteronism is characterized by low levels of renin and potassium, hypersecretion of aldosterone and high blood pressure. Causes Most often, primary hyperaldosteronism is observed in the following pathological conditions:.

benign and malignant tumors of the adrenal glands (primarily adrenal cortex adenoma); hyperplasia of the adrenal cortex. Secondary hyperaldosteronism develops against the background of:.

excess potassium intake; increased sodium loss; hypersecretion of renin; a sharp decrease in the volume of circulating fluid; pregnancy; redistribution of extracellular fluid, which leads to a decrease in the filling of large vessels with blood. Forms There are two main forms of the syndrome:.

Primary hyperaldosteronism (excessive production of aldosterone is associated with increased activity of the cellular structures of the glomerular adrenal cortex). Secondary hyperaldosteronism (excessive secretion of aldosterone is provoked by disorders in other organs). Hyperaldosteronism can be associated with disorders of the adrenal glands themselves or other organs Primary hyperaldosteronism, in turn, is of the following forms:.

idiopathic hyperaldosteronism (IHA) - bilateral diffuse hyperplasia of the glomerular zone; aldosteroma (aldosterone-producing adenoma, APA, Connes syndrome); primary unilateral adrenal hyperplasia; aldosterone-producing carcinoma; familial type I hyperaldosteronism (glucocorticoid-suppressed); familial type II hyperaldosteronism (glucocorticoid-unsuppressed); aldosteronectopic syndrome with extra-adrenal localization of aldosterone-producing tumors (in the ovary, thyroid gland, intestines). In women, primary hyperaldosteronism is recorded 3 times more often, manifestation occurs after 30 years. There is also pseudoaldosteronism - a condition when the main clinical symptoms of hyperaldosteronism (high blood pressure, hypokalemia) are detected against the background of a decrease in the concentration of aldosterone in the blood plasma.

Signs for primary hyperaldosteronism are characterized by:.

hypertension (increased blood pressure), accompanied by headache of varying intensity; hypokalemia (clinically manifested by increased fatigue, muscle weakness, convulsions); vascular lesions of the fundus; polyuria (constant feeling of thirst, frequent urge to empty the bladder at night, decreased urine density); psychoemotional disorders (asthenia, hypochondria, anxious readiness, depression).

High blood pressure is a common symptom of hyperaldosteronism The most common clinical manifestations of secondary hyperaldosteronism, in addition to symptoms of the underlying pathology, are:.

increased blood pressure; alkalosis; decrease in the level of potassium in blood plasma. Features of the course in children In children, hyperaldosteronism manifests itself in the form of Liddle syndrome, which manifests itself in the first 5 years of a child's life. It is characterized by:.

severe dehydration; increasing hypertension; lag in physical and psycho-emotional development.