After delving into metabolic problems, the research team found that enterochromaffin cells, which line the gastrointestinal tract, and are the source of almost all serotonin in the body, change in mice under the influence of a high-fat diet.

Study published in Neurogastroenterology \u0026 Moility.

Despite the known metabolic role of serotonin derived from the intestines, the main causes of increased serotonin levels in obesity and diabetes remain unknown..

The study offers a new understanding of the mechanisms by which functional changes in cells occur that can contribute to the change in circulating serotonin observed in obesity and metabolic diseases, and related gastrointestinal upsets, including gastroparesis and nausea..

The activity of the intestinal derivative of serotonin in these metabolic processes has direct consequences of metabolic disorders such as obesity and type 2 diabetes.

“At first, we showed that these cells have the ability to sense and secrete serotonin in response to the choice of nutrients in healthy conditions, which depends on their location in the intestine,” says Dr. Martin. “Now we have shown that nutrition, as well as the number of cells, affects diet in the diabetic model.”.

We are moving in several directions to understand the dynamic relationship that serotonin-producing enterochromaffin cells have with their intestinal environment in order to ultimately influence physiological processes, such as bowel function and metabolism. ”.

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