A Japanese research team has successfully developed a system to predict the severity of Alport syndrome, a serious inherited kidney disease. Patients with Alport syndrome have abnormalities in protein, type IV collagen, which often lead to chronic renal dysfunction requiring dialysis. Without a kidney transplant, the patient may experience kidney failure and death..
Researchers from Kumamoto University and Kobe University have demonstrated that disease severity can be predicted by analyzing the genotype of the type of collagen mentioned above..
“Significant advances in technology analyzing the genome enable comprehensive analysis of disease-related genes. We expect this study to significantly improve the definition of various hereditary diseases, including Alport syndrome, ”said Tsuyoshi Shuto, who co-wrote the study..
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