Researchers from Oklahoma used the latest methods of genetic analysis, which allowed us to discover a new, promising biomarker of glioma - the most common malignant brain tumor, according to the online publication for girls and women from 14 to 35 years old Pannochka. net This marker is of great importance for the early diagnosis of glioma.

This was reported in the January issue of Neurosurgery, the official journal of the US Congress of Neurosurgeons, published by Lippincott Williams \u0026 Wilkins.

Recall that glioma is a collective term that refers to all tumors originating in the glial cells of the brain and spinal cord. Glioma accounts for about 40% of all brain tumors and 80% of all CNS malignancies. With glioma, especially with multiform glioblastoma (GBM), patient survival remains extremely low.

According to study author P. Towner of the Oklahoma Medical Research Foundation, ELTD1 biomarker can serve as an additional marker of glioma in preclinical and clinical diagnosis.

A new biomarker talks about the rapid development of blood vessels.

Dr. Towner and colleagues have used new techniques to evaluate genes and their products that may be associated with glioma. Of the 200 substances analyzed, ELTD1 was selected as the best candidate for the role of a tumor biomarker.

A special interest in ELTD1 arose also for the reason that it is associated with the development of blood vessels (angiogenesis). As is known, enhanced angiogenesis is characteristic of rapidly growing tumors..

Human studies have shown a clear relationship between the degree of glioma and the level of ELTD1 biomarker. ELTD1 expression was higher in 50 patients with advanced glioma compared with 21 patients with advanced cancer. ELTD1 levels were comparable to other known glioma markers, such as vascular endothelial growth factor (VEGF).

In further experiments, the researchers transplanted glioma cells into rat brain. As tumors developed, their levels of ELTD1 increased..

Experiments in rats included a molecular MRI technique that measured the level of ELTD1 in brain tissue..

Today, GBM and other types of gliomas are very dangerous diseases with high mortality, despite modern treatment methods.. In recent years, advances in research have helped discover some biomarkers associated with glioma.

Dr. Towner and colleagues believe that identifying new GBM markers can lead to a significant improvement in the early diagnosis and treatment of this type of cancer..

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