Scientists have managed to create blood vessels of mice using human stem cells, which can potentially lead to the creation of new methods of treating cardiovascular diseases; the results of the study are published in the journal PNAS Early Edition.

Researchers from the Massachusetts Hospital (MGH) carried vascular precursor cells derived from pluripotent stem cells (iPSCs) of human origin (reprogrammed adult cells similar to embryonic stem cells) from the group of healthy adults to the group with type 1 diabetes mellitus (T1D ). Further iPSCs were implanted on the surface of the brain of mice, according to an online edition for girls and women from 14 to 35 years old Pannochka. net The results showed that within two weeks the implanted cells formed blood vessel networks that functioned in the same way as natural vessels and lasted for 280 days. Scientists also implanted iPSCs to create blood vessels under the skin of mice. Although this procedure was successful, it requires five times more cells, and the resulting blood vessels do not last long.

According to the Center for Disease Control and Prevention (CDC), cardiovascular disease is the most common of the diseases in the US. The ability to regenerate or restore blood vessels, according to physicians, could significantly improve the situation in the treatment of cardiovascular diseases and others caused by damage to the blood vessels, for example, vascular complications resulting from diabetes.

"The discovery of ways to bring mature cells back to the" stem state ", can change the state of various types of tissues and attests to the enormous potential in the field of cellular regenerative medicine. Nevertheless, the problem of obtaining functional cells from iPSCs still remains, "says Rakesh Jane, director of the Stell's Laboratory of Tumor Biology at the Massachusetts General Hospital.

The researchers also found that cells derived from iPSCs in patients with type 1 diabetes have the ability to create long-lasting functioning blood vessels. Nevertheless, the researchers add, the cells of patients with diabetes mellitus have different levels of cell generation potential, so further research is needed in this area.

"The potential for the use of blood vessels generated from iPSCs is very wide:

from repairing damaged vessels that supply blood to the heart or brain, to preventing limb amputations due to vascular complications from diabetes mellitus. But first we must deal with such problems as the variability of iPSCs chains and the long-term safety issues associated with the use of these cells. We also need better ways to design a specific type of endothelial cell, which is necessary for specific organs and functions, "says co-author Rekha Samuila.

medbe. en.

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