Diagnosis of diabetes mellitus (DM) type 2 under the age of 50 years is associated with an increased risk of microvascular complications, according to an online edition for girls and women from 14 to 35 years old Pannochka. net This conclusion can be drawn on the basis of the results of the international study ADVANCE.

During the study, the researchers found that the risk of microvascular complications of diabetes, such as eye and kidney damage, depends on the duration of the disease, and not on the patient's age.

The risk of serious macrovascular events, such as myocardial infarction, stroke, as well as mortality due to all causes, depends both on the age and duration of the disease. This was stated at the World Congress on Diabetes, Dr. John Chalmers, who heads the study ADVANCE.

"The results suggest that if you are diagnosed with type 2 diabetes at an early age, then you may have a more aggressive, fast-progressing and treatment-resistant form of the disease. It is very important to know about this in order to closely monitor the level of glucose and check the condition of your kidneys and eyes, "said Dr. Chalmers, director of the George Institute in Sydney and honored professor of medicine at Sydney University.

The ADVANCE study is a randomized study in 20 states that examined the effects of antihypertensive therapy and various methods of glucose control on diabetes in 11,140 adult participants over 5 years. The mean age at the time of enrollment was 66 years, the average duration of the disease was 7.9 years.

"You may think that the older the participants in the study, the more they have the average duration of diabetes, but this is not necessary," the doctor said in an interview.

In the ADVANCE study, 7.5% of patients with a duration of diabetes less than 5 years already had serious microvascular complications, and among those who lived with diabetes for more than 15 years, such were already 18.6%.

Patients in the second group, that is, who have been ill for more than 15 years, suffered from diabetes on average from 47 years of age. Patients from the first group were diagnosed with diabetes mellitus much later - at an average age of 63 years.

The study showed that participants with the longest duration of the disease had a higher level of hemoglobin A1c compared to participants in the first group (7.9% vs. 7.2%).

"Serious macrovascular events are increasingly emerging as patients age and the duration of the disease increases - both of these factors have an independent effect.

Microvascular complications are more dependent on the effect of elevated glucose levels, while macrovascular events are influenced by traditional risk factors such as hypertension, cholesterol, and smoking, "the doctor said..

The ADVANCE study was partially funded by Servier, a manufacturer of Preterax (perindopril plus indapamide), known under the brand name Noliprel.

Dr. Chalmers indicated that he received a research grant and a fee from the company for conducting this work.

medbe. en.