If a woman suffers from hypertension, the substance pentaerythritol tetranitrate (TEN) can protect her female offspring from the development of this disease, according to the Internet edition for girls and women from 14 to 35 years old Pannochka. net It is interesting that the heater is an explosive similar to those used in dynamite and gunpowder.
These data were published in the journal Hypertension.
Errors in nutrition, lack of physical activity, obesity and alcohol abuse are known to all risk factors for hypertension. But these factors can be controlled. What can not be said about others, such as weighed heredity - the presence of hypertension in close relatives.
Researchers from the University of Johann Gutenberg in Mainz (Germany) say that one day this discovery can change the fate of women whose mothers suffered from hypertension.
In the course of their scientific work, German scientists established that pentaerythritol tetranitrate (a substance close to nitroglycerin) and nitrocellulose (the main component of gunpowder) prevent the development of hypertension in rats born by animals with inherited disease.
Every day throughout the period of pregnancy and lactation, scientists gave pregnant high-pressure rats at 50 mg TEN per kilogram body weight. The drug was mixed into the feed.
The TEN can initiate changes in the genes of the female offspring that lead to a lowering of blood pressure. According to the researchers, TEN does not affect the pressure in pregnant rats. But the systolic pressure of the females that they give will be on average 10-13 mm. ppm. art.. below.
Pentaerythritol tetranitrate did not affect the pressure in male offspring. In the control group that did not receive TEN, no changes in pressure were observed in the offspring.
Scientists believe that the TEN causes genetic changes that contribute to the accumulation of more molecules responsible for relaxation of blood vessels and a decrease in pressure.
This hypothesis is based on the fact that TEN and nitroglycerin are already used to treat angina pectoris - a heart disease caused by a narrowing of the coronary arteries. Both substances are referred to donators of nitric oxide, and the mechanism of their action is to expand the vessels.
The co-author of the study, Dr. Lee, a professor at the Department of Pharmacology at the University's Medical Center, Johann Gutenberg, says that nitroglycerin is the optimal drug for stopping angina attacks because it acts quickly.
"For the prevention of seizures, other drugs are recommended, but nitroglycerin is still a sought after remedy. Although with prolonged use, a phenomenon of tolerance to nitrates. TEN is a very important option if it is a long-term treatment. At least, experiments on animals have not revealed tolerance to the TEN, "- says Dr. Lee.
Although the results of the study are encouraging, Dr. Lee says that they should be interpreted with caution:
"Although the ability of the HEAT to reprogram cells during the intrauterine development period has great prospects, we can not safely talk about transferring the results to humans. We must first of all evaluate the long-term safety of the heater for the offspring, and only then can it be considered an option for treating hypertension in humans ".
Last month, the American journal JAMA Dermatology reported that people with severe psoriasis are at increased risk of hypertension compared to people with healthy skin.
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