Adolescents with obesity and insulin resistance have an elevated level of two proteins, A? 42 and PSEN1, which are considered biomarkers predicting Alzheimer's disease.
A study in Italy showed that a high level of these proteins in adolescents with obesity is more common than in their peers with normal weight.
But this can not be said of pre-school children.
"The clinical significance of our observation is still unclear, but longer studies will help us to solve this riddle," writes lead author Dr. Rosa Luciano, an employee of the department of laboratory medicine at the Children's Hospital Bambino Gesu in Rome, in the online journal Pediatrics..
Alzheimer's disease, as the scientist knows, involves the violation of insulin mechanisms in the brain. That's why people with type 2 diabetes often develop dementia. Dr. Luciano and her colleagues suggested that the connection between obesity, insulin resistance and abnormalities in the brain is laid already in early childhood.
The A? 42 peptide is a longer version of beta-amyloid, the deposits of which play an important role in the development of Alzheimer's disease. Another biomarker, PSEN1, is a complex that forms the peptide A? 42, and which can cause insulin resistance in brain cells. Previous studies have shown that in elderly people with elevated A? 42 levels, Alzheimer's disease is more likely to develop in the future.
Dr. Luciano decided to analyze the blood samples of white preschoolers (age 2.0-5.8 years) and adolescents (age 12.0-17.8 years) who participated in two other studies organized by the children's hospital Gesu Bambino. Children did not have any chronic diseases, endocrine disorders, or recent infections; they did not take drugs that could affect the growth or metabolism of carbohydrates.
Adolescents with obesity had a higher PSEN1 level than their peers with normal weight (P <0.0001), as well as a higher A? 42 level (? = 0.262, P <0.0001). Statistical analysis showed that both biomarkers correlate with insulin resistance.
It is interesting that in preschool children the level of A? 42 and PSEN1 does not depend on body weight.
In general, the new study left scientists with more questions than answers. In the near future, they are going to organize a more extensive study to try to establish the consequences of increased content of A? 42 and PSEN1 in adolescence.
medbe. en Adolescents with obesity and insulin resistance have an elevated level of two proteins, A? 42 and PSEN1, which are considered biomarkers predicting Alzheimer's disease.
A study in Italy showed that a high level of these proteins in adolescents with obesity is more common than in their peers with normal weight.
But this can not be said of pre-school children.
"The clinical significance of our observation is still unclear, but longer studies will help us to solve this riddle," writes lead author Dr. Rosa Luciano, an employee of the department of laboratory medicine at the Children's Hospital Bambino Gesu in Rome, in the online journal Pediatrics..
Alzheimer's disease, as the scientist knows, involves the violation of insulin mechanisms in the brain. That's why people with type 2 diabetes often develop dementia. Dr. Luciano and her colleagues suggested that the connection between obesity, insulin resistance and abnormalities in the brain is laid already in early childhood.
The A? 42 peptide is a longer version of beta-amyloid, the deposits of which play an important role in the development of Alzheimer's disease. Another biomarker, PSEN1, is a complex that forms the peptide A? 42, and which can cause insulin resistance in brain cells. Previous studies have shown that in elderly people with elevated A? 42 levels, Alzheimer's disease is more likely to develop in the future.
Dr. Luciano decided to analyze the blood samples of white preschoolers (age 2.0-5.8 years) and adolescents (age 12.0-17.8 years) who participated in two other studies organized by the children's hospital Gesu Bambino. Children did not have any chronic diseases, endocrine disorders, or recent infections; they did not take drugs that could affect the growth or metabolism of carbohydrates.
Adolescents with obesity had a higher PSEN1 level than their peers with normal weight (P <0.0001), as well as a higher A? 42 level (? = 0.262, P <0.0001).
Statistical analysis showed that both biomarkers correlate with insulin resistance.
It is interesting that in preschool children the level of A? 42 and PSEN1 does not depend on body weight.
In general, the new study left scientists with more questions than answers. In the near future, they are going to organize a more extensive study to try to establish the consequences of increased content of A? 42 and PSEN1 in adolescence.
medbe. en.