Women who entered the phase of menopause may in the long term abandon hormonal drugs. They will save the new ovaries grown in the laboratory. It is known that hormone replacement therapy, designed to cover the lack of estrogen, increases the risk of heart disease and breast cancer.
And, according to employees of the Institute for Regenerative Medicine Wake Forest, artificially created ovaries are more effective and safer than hormone therapy. They are able to improve the condition of bones, uterus and total body composition. This was proved by experiments with rats. Ovaries isolated hormones in a natural way, relying on the real needs of the body. It turns out that an overdose is excluded.
So, to get an artificial ovary, scientists had to isolate two types of cells from the ovary of rats (granulosa and teka cells). As a capsule containing cells in itself, a thin membrane was used. Capsules were implanted in rats whose own ovaries were removed.
These animals were compared to normal animals, as well as to animals receiving hormonal preparations in large and small dosages. Scientists were interested in the overall composition of the body, the health of bones and uterus, because, as is known, with fattening ovaries, fat accumulation and weight gain occur. Therefore, it can be considered a success that the artificial ovaries allowed less typing of adipose tissue than small doses of hormones.
It is also known that estrogen deficiency contributes to the development of osteoporosis, fractures.
Just in rats with artificial ovaries bone tissue looked better than in animals on hormone therapy. With regard to the work of the genital and urinary systems (also suffer from the extinction of ovarian functions), the condition of the uterus in rats with its and with artificial ovaries was identical.
Scientists emphasize: women will have to transplant donor cells. And the capsule will have to be made breathable so that oxygen and nutrients freely penetrate it. This will avoid implant rejection.
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