The etiology of this disease is not fully understood. There is speculation that erythema multiforme is a multifactorial allergic disease, which is based on a delayed hypersensitivity or immediate type to infectious agents or drugs.

The main causes identified as significant in the development of the disease:.

viral and microbial infections,.

antibiotics and sulfonamides,.

phenobarbital,.

in children, the vaccination of DTP is causally important,.

supercooling, solar insolation,.

skin trauma.

Clinical manifestations.

The period of prodromal phenomena lasts about three to four days. There is a general malaise, an increase in temperature to 37. 0-37. 5 degrees. There may be angina, redness of the throat, a respiratory phenomenon, lethargy or weakness, aches in muscles, joints or bones.

Rashes occur on the back surface of the feet and brushes, from the extensor surfaces of the hips, legs or forearms, can be on the face and neck, on the trunk. Elements of a different nature - spots, bubbles, blisters, tubercles, vesicles. In the central part of the bubble elements, the lining of the lid is revealed, along the edges a roll-like thickening due to swelling. In the center there may be vesicular rashes.

The heavy, bullous form gives bubbles with bloody contents that are opened with the formation of erosions, which then form a bloody crust. Skin and mucous membranes of the mouth, eyes and genital organs may be affected. Rashes last for up to four to six weeks and are. In a third of patients, relapses are possible in the future.

Diagnostics.

The basis of the diagnosis - typical manifestations of the disease and polymorphic rash, localized in typical places, the seasonality of the occurrence, a special form of rashes, similar to flowers of iris. This form of the disease must be distinguished from other dermatitis - bullous impetigo, Lyell syndrome, toxicermia or herpes lesions.

Methods of treatment.

Severe dermatitis involves inpatient treatment with individual skin care, hormone therapy. Apply prednisolone or its analogs to the gradual resolution of elements of the rash. Also used antibiotics, antiviral drugs, detoxification with intravenous injection of hemodez, albumin and plasma, glucose. Assign gamma globulin to muscle.

An easy course involves treatment at home with calcium supplements, antihistamines, vitamins. External therapy is carried out by using aniline dyes, hydrogen peroxide, ethacridine. Mucous are treated with solutions of antiseptics. With a decrease in inflammation, epithelial ointments are used.

Forecast.

After the transferred mono-form erythema, the dispensary registration and prevention of allergic reactions. The prognosis is favorable, although in some cases, recurrence of the disease in a lighter form is possible.

dr20. en.