Studying natural rejuvenating substances, scientists came across the fantastic result of a long joint evolution of plants, bacteria and animals.

They discovered a substance that helps the muscle cells of animals and humans to protect themselves from the damaging effects of aging.

This urolitin A - a natural molecule, synthesized in the intestine of garnets under the influence of special bacteria.

Effects of urolitin A have not yet been fully studied, but this substance has every chance to be the elixir of youth, which millions of people dream of.

On the unusual substance and healing properties of garnets reported in the journal Nature Medicine staff of the Federal Polytechnic School in Lausanne, Switzerland.

In general, there are many rumors about the benefits of garnets. But the lack of scientific evidence, as well as contradictory marketing, make one look at all this with skepticism.

Nevertheless, the Swiss scientists decided to literally disassemble the molecules not only the garnet itself, but everything that is formed from it in the digestive tract.

Unnecessary mitochondria.

As the aging process in our cells slows down the processes of obtaining energy, in connection with which we are less tolerant of the load. There is a wear and death of mitochondria, small cell power plants.

If the "decommissioned" mitochondria are not disposed of, then this cell debris gradually accumulates inside the cells, poisoning everything around, but the energy becomes less.

For garbage collection, nature provided for the mechanism of mitophagy - the utilization of mitochondria. But it does not always work - in this case, wait for serious problems.

There is scientific evidence that worn out mitochondria are involved in the development of Parkinson's disease and a number of other senile diseases. Recently, it was found that a defective gene, predisposing to Parkinson's disease, violates mitophagy.

Urolitin A restarts mitophagy.

Employees of the EPFL found that urolitin A can not only restart mitophagy, but also significantly accelerate this process, activate the purification of cells from free radicals.

"This is by far the only molecule capable of restoring the process of mitochondrial utilization. A completely natural substance with a powerful effect, "says Professor Neurosciences Professor Patrick Aebischer, co-author of the study.

Professor Ebisher's group tested the effects of urolithine A on Caenorhabditis elegans. These nematodes are a valuable model for studying human biology, because they are multicellular, their cells are very similar to ours, they grow rapidly, and develop from a fertilized egg.

Ebisher explains that at the age of 8-10 days these nematodes are already considered old, so the model is ideal for studying cell aging.

Here and in the last study C. Elegans under the action of small doses of urolitin A lived on average two weeks, which is 45% longer than their normal life expectancy.

Such a serious success was due to the fact that urolitin A prevents accumulation of dysfunctional (spent) mitochondria in the process of aging worms.

Increased Stamina.

After a series of experiments on rodents, scientists were delighted.

Under the influence of urolitin A, laboratory mice not only lived much longer than they were supposed to, but also at 2 years of age (mouse old age) showed a 42% better tolerance of exercise.

"All tests and tests confirmed that in mice, due to urolithin A, the utilization of mitochondria was accelerated, and cells were cleared of free radicals," say scientists.

Nematode C. Elegans and rodents are very far from each other evolutionarily, but on both species the unique substance has a beneficial effect.

This is a good sign. The authors believe that urolitin A is a universal recipe for youth, almost for all living creatures, including humans.

Grenades will not help everyone.

Although the results look simple and bright, using grenades is only one of the conditions of longevity. The fact is that the molecule of urolitin A is not contained in garnets.

They include a precursor molecule from the group ellagitannins - partially hydrolyzable tannins. When this substance is mixed with water, it is cleaved to ellagic acid - this is the next stage of production of urolyte A.

At the final stage, special intestinal bacteria.

Due to the very complex multistage synthesis and the participation of microorganisms, the amount of urolyte A produced in the body varies widely. In fact, some people may not have the right bacteria, so grenades are useless.

Biotechnology will rejuvenate our cells.

If you are among the people who have not synthesized urolitin A in their intestines, then modern biotechnologies will come to your rescue.

The Swiss researchers founded a start-up project called Amazentis.

They developed an original method of delivering accurate doses of urolithin A to the body, which they intend to introduce into medical practice for the rejuvenation of the body and prevention of a number of age-related diseases.

medbe. en.