Virtually all drugs from type II diabetes protect patients equally from cardiovascular events, according to an online edition for girls and women aged 14-35 who have been diagnosed with Pannochka. net None of the hundreds of clinical trials has confirmed the superiority of any one sugar reducing drug, combination or group of drugs over the rest.
The authors of a recent study conducted in the Cleveland Clinic (USA), in the light of this information, recommend starting treatment with the cheapest and proven means - metformin.
According to endocrinologists of the renowned clinic, metformin is the most suitable for most diabetics.
"Our experts are few in what issue are so unanimous. Metformin, in the absence of contraindications or intolerance, should be considered as a first-line drug for the treatment of patients with type 2 diabetes mellitus. Initially, there is no need to use more expensive alternatives, "says Kevin Pantalone, a diabetologist at the Cleveland Clinic, a member of the US Endocrine Society.
Metformin can cause dyspepsia and diarrhea, which is why some patients are unable to take it daily. People with severe kidney disease should also not take metformin.
For such patients, the pharmaceutical industry offers a huge assortment of other medicines. But until recently it was unclear how well these or other drugs protect against the far-reaching consequences of diabetes - heart attack, stroke, thromboembolism, etc..
The new study was never able to determine the winners.
It included the results of 301 clinical trials conducted in different countries of the world with 9 groups of drugs: insulin, metformin, glipizide, glimepiride, pioglitazone, rosiglitazone, sitagliptin, saxagliptin and others..
"To date, there is not enough scientific evidence that one drug prolongs the lives of diabetic patients more than others, both with monotherapy and in combinations. But the problem is just the lack of data, "- warn the American endocrinologists.
According to Dr. Pantalone, the two newest drugs, lyroglutide (Victoza) and empagliflozin (Jardiance), are able to curb cardiovascular risk, but the evidence is in this case too small.
"And yet, taking into account all the pros and cons, I primarily recommend metformin. It does not just cut sugar perfectly, it also causes less hypoglycemia than other drugs.
If you need to add something else to the metformin, then this decision should be individual, depending on the health status and tolerability of the drugs - sulfonylurea derivatives often lead to hypoglycemia, others contribute to weight gain, "explains the researcher..
But whatever medicine you choose, changes in lifestyle will be a key condition for the treatment of Type II diabetes mellitus. Regular motor activity and the right diet are the key to longevity and well-being, which will not replace you even the most expensive tablets.
Read more about this in the Journal of the American Medical Association.
medbe. en.