The cases of locally distributed breast cancer, related to the stage of Sha, formally are primarily operable, although in terms of their biological characteristics their operability is conditional. For this category of patients, pre-operative therapy is preferable. A preoperative XT may allow a smaller operation to be performed than it could have been initially planned for breast cancer at stage II, according to an online edition for girls and women aged 14-35 who have been diagnosed with Pannochka. net The need to start treatment of locally advanced breast cancer with chemotherapy (XT) was demonstrated by Fourquet A. et al. (1993). The authors compared the efficacy of two sequences in XT and radiation therapy in 390 breast cancer patients T2-3N0-1 MO. Half of the patients received 4 courses of XT according to the CAF scheme, then - local treatment; other 50% - first local treatment, then - XT. The four-year survival rate of the former was 89%, the second 80% (p = 0.046).
The benefits of treatment, including the first stage of XT, were also presented by Semiglazov V. et al. (1994). 271 patients with BC breast cancer. - Sha stages were randomized to carry out: XT according to the TMF scheme (thio-phosphamide, methotrexate, 5-fluorouracil) in combination with radiotherapy (group 1, 137 patients); or only preoperative radiotherapy (group 2, 134 patients). A radical mastectomy was performed and 4-6 courses of XT were performed according to the TMF scheme. In a morphological study, complete regression of the tumor was observed in 29% of cases of the 1st group and in 19% of the 2nd group. The 5-year OS was 86% and 78% (p> 0.05), the 5-year-old DBV was 81% and 72% (p <0.05), respectively.
The well-known thesis that the efficacy of XT directly correlates with the intensity of the dose of chemotherapy in the treatment of disseminated breast cancer and in the adjuvant XT after radical surgery has been confirmed for preoperative XT. So, Shparik J. (1996), a secondary analysis of the published results of 41 studies on preoperative chemotherapy of breast cancer.
Treatment regimens included cyclophosphamide (31 studies), 5-fluorouracil (26), doxorubicin (24), epidoxorubicin (13), methotrexate (9), vincristine (6), mitoxantrone (3), cisplatin (2), mitomycin C 1) and thiophosphamide (1). A direct relationship between the ID of chemotherapy and the effectiveness of treatment.
When asked which XT regimens are most effective in preoperative treatment, there is no unambiguous answer in the literature. Most of the studies are exploratory in nature and are devoted to the evaluation of new antitumor drugs or those previously used in the second line of XT, as well as an increase in ID of drugs.
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