In the absence of special instructions, take medications 20 to 30 minutes before meals, when they are best absorbed, but this is not true for all medicines.

The fact is that the acid-base reaction in the stomach and in the lower parts of the digestive tract before meals, during and after meals changes. If a certain acid-base reaction is required to maintain and absorb a particular drug, such a drug should be taken sometimes during meals, and sometimes after. For example, agents that irritate the gastric mucosa (acetylsalicylic acid) are recommended to be taken during or after a meal.

The correct intake of the drug also affects the duration of its action. So, for example, antacids used in the treatment of peptic ulcer of the stomach and duodenum, when administered on an empty stomach, last about half an hour, and when administered 1 hour after meals - "work" 3 - 4 hours.

It should be remembered that in order to maintain a constant concentration of the drug in the blood, the medication should be taken regularly at regular intervals. That is, the drug taken 3 times a day should be drunk every 8 hours, and not only during the day.

Than to wash down That, than we wash down medicines, can considerably influence efficiency of a preparation. Remember, it is best, if there are no special instructions, to wash down with clean water. Water is a good solvent and does not affect the active substance.

Many people think that it is useful to take drugs with milk. Indeed, this product reduces the irritating effect on the wall of the stomach, for example, acetylsalicylic acid and other anti-inflammatory drugs. Recommend to drink milk also preparations of iodine, vitamins A, D, E, K. Milk reduces the effectiveness of drugs that are similar in structure to proteins - cardiac glycosides, caffeine, antiulcer drugs (cimetidine, ranitidine). Do not drink milk enzymes (pancreatin, mezim). Milk inactivates tetracycline preparations, since the calcium contained in the milk forms with the drug components an insoluble compound. Sometimes in the annotation to the drug, you can find a direct mention of the inadmissibility of drinking milk. For example, the manufacturer hilak forte indicates: "take with a small amount of liquid (excluding milk)".

Do not drink medicine and tea. The fact is that tea contains tannin, which forms insoluble compounds with nitrogen-containing drugs, the latter are quite a lot: papaverine, codeine, euphyllin, cardiac glycosides and t.

Acidic fruit and vegetable juices adversely affect the effectiveness of antibiotics such as erythromycin, sumamed, ampicillin, and, conversely, significantly increase the activity (up to toxic effects) of aspirin, nitrofurans (furagin, furazolidone), paracetamol, ibuprofen. There are reports that serious complications can be noted when used with grapefruit juice medicines. This is due to the fact that the components of juice, affecting the enzyme systems of the liver, change the effect of a large group of chemicals, which leads to unpredictable consequences of taking the medicine.

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