Scientists from the University of Carolina (Sweden) found that the ability of the body to splinter drugs directly depends on sunlight, and, consequently, on the time of year.

These data help in a new way to look at individual differences in the effects of drugs and on how external factors affect the body's ability to neutralize toxins.

The study is based on the results of 70 000 analyzes from patients who regularly checked blood levels of blood. It is about drugs that suppress the immune system, which are prescribed for organ transplants. Scientists compared the analyzes taken during the winter with the analyzes taken during the summer.

It turned out that the concentration of such drugs as tacrolimus and sirolimus in the blood changes significantly throughout the year and coincides with changes in the level of vitamin D in the body. The ability of the body to produce vitamin D depends on how much sunlight gets a person. According to the study, the time when the body had the highest level of vitamin D, coincided with the lowest concentration of the drug in the blood.

Scientists say that vitamin D activates in the liver enzymes of the CYP3A4 system, which helps to break down and remove toxins from the body.

This system of enzymes also participates in the metabolization of tacrolimus and sirolimus.

"If the body is stronger destroys the drug, then higher doses are needed to achieve the effect. Further research is needed on this topic, but it is already clear that the CYP3A4 system, which is the most important enzyme system in the body, can in the same way change the exchange of many other drugs, "says Jonatan Lindh, the study's lead author.

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