Recent studies have shown that transmembrane type II serine proteases play an important role in the normal functioning of cells and in various pathological processes. However, the expression of these molecules and their function in the cells of the central nervous system are still insufficiently studied, according to the Internet publication for girls and women from 14 to 35 years old Pannochka. Net Chinese scientists from Taiwan's National Health Research Institution in their study showed that one member of the family of transmembrane type II serine proteases, matriptase (MTP), is expressed almost exclusively by neuronal progenitor cells (NP) and neurons.

It was found that blocking the expression or activity of MTP makes it impossible to migrate NP through the main membrane, whereas increased expression of MTP stimulates such migration. The mobilization of NP caused by the vascular endothelial growth factor (VEGF) or hepatocyte growth factor (HGF) also stops when the MTP expression is turned off. Thus, it is shown that MTP stimulates the migration of neural progenitor cells; This effect is mediated by an increase in the activity of matrix metalloproteinase 2.

With the directed differentiation of embryonic stem cells into nerve cells, switching off the expression of MTP does not affect the direction of differentiation.

However, increased expression or MTP activity affects the population dynamics of neural progenitors, favoring their differentiation into neurons.

In this study, direct participation of MTP in NP. According to Dr. P. Katunyan, the head physician of the Moscow Center for Biomedical Technologies, these results can be used to control the differentiation and migration of neural progenitor cells, which will improve the methods of cell therapy for neurodegenerative diseases.

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