In many tissues of an adult organism, mesenchymal stem cells (MSCs) are closely associated with perivascular niches and express many common pericyte markers. The ability of pericytes to act as stem cells, however, remains unproven, according to an online edition for girls and women aged 14 to 35 years Pannochka. Net British scientists from Kings College London, using the methods of genetic linear tracing, have shown that in vivo in response to tissue damage and with the growth of the tooth, some pericytes give rise to mesenchymal cells that differentiate into specialized odontoblasts. In this case, a significant part of the odontoblasts is derived from MSC of non-peritic origin.

Thus, pericytes can be an additional source of MSC migrating to the site of tissue damage and differentiating into cells of mesenchymal origin.

The results of this study indicate the dual origin of MSCs in the same tissue.

Apparently, the contribution of pericytes to the formation of MSC in different tissues is different and depends on the degree of tissue vascularization.

According to Dr. P. Katunyan, the head physician of the Moscow Center for Biomedical Technology, a study of British scientists provides new valuable information on the biology of stem cells and tooth formation processes, which will allow the development of techniques for tissue engineering of teeth in vivo.

News. Gradusnik. En.

Keywords:.