Stem cells in combination with microcarriers of drugs for the treatment of Parkinson's disease

06 May 2017, 19:24 | Health
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Multipotent mesenchymal stromal cells (MSCs) are of great interest as a tool for cell therapy, in particular, brain diseases. This is due to the ease of obtaining them from the bone marrow, with their immunomodulating and tissue regenerating capabilities, their ability to differentiate into nerve cells and to isolate a variety of different growth factors and chemokines.

A group of French scientists from the Institut National de la Sante et de la Recherche Medicale evaluated the therapeutic effect on rats with Parkinson's disease of concomitant administration of human MSCs and pharmacologically active microcarriers (FAM). A special subpopulation of bone marrow derived MSCs was used - multilinear inducible stem cells. FAM were biodegradable poly-lactic-co-glycolic acid microspheres with biomimetic coating releasing therapeutic proteins that act on cells.

In this study, FAM were coated with laminin and released neurotrophin-3 (neurotrophin 3, NT3), stimulating neuronal differentiation of MSCs and improving the survival of nerve cells. In MSK induced differentiation in dopaminergic neurons in vitro, after the adhesion of these cells to the FAM, they were implanted into the striatum of parkinsonian rats. As a result, the nigro-stratal pathway was restored, and rat behavior significantly reduced the amphetamine-induced rotation behavior. This effect was correlated with an improvement in the survival rate of transplanted MSCs secreting a variety of growth factors and cytokines. In addition, growth of tyrosine hydroxylase expression was observed in transplanted cells on the FAM cells, which also could contribute to the restoration of functions.



Thus, the obtained results indicate an increase in the effectiveness of cell therapy of Parkinsonism when using MSC in combination with microcarriers that release growth factors.

According to Dr. P. Katunyan, the head physician of the Moscow Center for Biomedical Technologies, the proposed technique after clinical trials can find practical application and significantly improve the results of cell therapy of Parkinson's disease and other neurodegenerative diseases.

News. Gradusnik. En.

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Based on materials: news.gradusnik.ru



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