When dividing the hematopoietic stem cells (HSC), daughter cells are formed that can both remain stem cells and enter differentiation, providing blood formation. To determine the rate at which GSKs are divided in the body of laboratory animals (eg, mice), the cells are labeled with special markers, but for humans this method is unacceptable.

A group of American scientists from the University of Nevada has developed a method for calculating the frequency of HSC fission in vivo, suitable for use in humans. The researchers analyzed the age-related changes in the relationship between the maternal and paternal X chromosome phenotype in women's blood cells and concluded that human HSCs are divided on average every 40 weeks (once every 25-50 weeks). These calculations were confirmed by two independent measurement methods, in particular the modeling of human hematopoiesis, the model being exactly consistent with the data obtained in the evaluation of hemopoiesis after transplantation.

It has been established that in humans the number of HSC from the moment of birth to the age of adulthood is constantly increasing, and then it remains constant, and the fraction of resting HSC in humans is different than that of the mouse.

The data obtained suggest that bone marrow failure, for example, in aplastic anemia, or failure of cord blood transplantation is the result of an insufficient number of HSCs, and an insufficient number of early progenitor cells.

According to Dr. P. Katunyan, the head physician of the Moscow Center for Biomedical Technology, this study provides a better understanding of the biological patterns underlying hematopoiesis, and its results can be used to develop methods for managing this process.

News. Gradusnik. En.

Keywords:.