Serotonin stimulates scarring of the liver, but it interferes with the restoration of working cells

21 April 2017, 22:06 | Health
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Serotonin, known as the hormone of happiness, stimulates scarring of the liver, but interferes with the restoration of the working cells of this organ. This conclusion was made by researchers from the British University of Newcastle, according to an online edition for girls and women from 14 to 35 years old Pannochka. Net As you know, with liver diseases everything depends on what process will be dominant: scarring of the liver due to connective tissue or the formation of new functional cells-hepatocytes. If scarring predominates, and the patient suffers from a chronic illness such as hepatitis, it can simply lead to cirrhosis or even liver cancer, according to compulenta. En.

British researchers have found a way to inhibit degeneration into connective tissue and to incline the liver to regeneration. When the liver is damaged (anyway from what - due to hepatitis, alcoholism, poor ecology and so forth. ), Platelets come to her aid. They carry out obscheremontnye work and abundantly allocate serotonin, "the hormone of happiness". Serotonin is not only the most important neurotransmitter, but also serves as an activator for platelets, increasing their ability to aggregate and form clots. He also stimulates in the liver the synthesis of coagulation factors.

But, as scientists write, serotonin can play against a sick liver.

Cells of Ito, or stellate cells of the liver, which form the scars, are sensitive to serotonin. The appearance of this hormone activates Ito cells and enhances scarring. However, if these cells disconnect the 5-HT2B receptor that they feel serotonin, this can increase the chances of the liver regenerating.

The researchers successfully suppressed the work of this receptor in the cells of mice, and so far there is no reason to doubt that this method will work on a person.

News. Gradusnik. En.

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Based on materials: pannochka.net



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