Women with a history of hypertensive disorders in pregnancy have a significantly higher risk of developing hypertension, kidney disease and stroke than women with normotensive pregnancy, said Catherine Brown (Mayo Clinic in Rochester, Minnesota) at the 44th Annual Meeting of the American Society of Nephrology.
Women with a history of hypertensive disorders in pregnancy have a significantly higher risk of developing hypertension, kidney disease and stroke than women with normotensive pregnancy, said Catherine Brown (Mayo Clinic in Rochester, Minnesota) at the 44th Annual Meeting of the American Society of Nephrology.
Dr. Brown and colleagues used the population longitudinal database "Rochester Epidemiology Project", which includes medical reports of residents from January 1, 1966 to the present. The database contains information on almost half a million people, and approximately 1.2 million medical reports from 65 different health subjects.
The researchers examined women who gave birth to children from 1976 to 1982 and were classified as having diagnostic codes compatible with hypertensive pregnancy disorders (cases) or without hypertensive pregnancy disorders (control). All subjects were evaluated after 40 years with regard to diagnostic codes compatible with adverse cardiovascular and renal outcomes.
For every woman of the case, a woman of control, without hypertensive pregnancy disorder in the current or previous pregnancies, was selected according to age, the order of birth and the calendar year.
The authors identified 6051 mothers who gave birth from 1976 to 1982. The average age of 607 women of the case was 26.4 years, and 5,444 control women - 26.7 years. Follow-up after 40 years was available for 77% (465 of 607) of the women of the case, and 72% (3898 of 5444) of the women of control.
The norm of the diagnostic code of any outcome was 62% for the women of the case, and 47% for the control women.
The average age of the first event for women with hypertensive pregnancy disorders is 44 (40-67), control women - 50 (40-72); Hypertension: for women with hypertensive pregnancy disorders - 236 (51%), control women - 1222 (31%), kidney disease:
for women with hypertensive pregnancy disorders - 63 (14%), women for control - 374 (10%), stroke : For women with hypertensive pregnancy disorders - 35 (8%), control women - 160 (4%).
There was no significant difference between the case and control groups for outcomes of coronary heart disease and venous thromboembolism. However, Dr. Brown suggests that the risk for coronary heart disease may have been underestimated because of the age of the cohort.
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