Ange Postecoglou's and Josep Guardioli's teams have experienced significant personnel losses in the cup duel.
Read about the match later on our website.
Tottenham - Manchester City 2:1 Goals: Werner, 5, Matar Sarr, 26 - Nunes, 45+5 Tottenham: Vicario - Gray, Romero (Devis, 52), Dregushin, van de Ven (Udoji, 14) - Matar Sarr (.
Manchester City: Ortega - Lewis, Stones, Dias (Guardiol, 46), Ake (Simpson-Pusi, 73) - Gundogan (Kovacic, 46) - Savio (Wright, 63), O'Reilly, Mackay, Nunes - Foden.
Next: Matar Sarr, Bissouma, Gray.