Under the influence of both tuberculous and syphilitic intoxication, the connective tissue undergoes profound constitutional changes. The amount of damage produced by the pallidum spirochete depends on the greater or lesser resistance of the connective tissue.. Syphilis, like tuberculosis, occurs in the connective tissue. There is no doubt that syphilitic intoxication of parents can cause in children a picture of lymphatic-hypoplastic diathesis, create an asthenic or pasty constitution.
Social diseases - syphilis, tuberculosis, alcoholism - cause irritative-hyperplastic processes in the connective tissue with its subsequent hardening.
Occupational toxicosis, overwork of the body, insufficient ventilation of the body with oxygen in the air should be added to these factors of the environment of life.. Where there is chronic tissue asphyxia, we find, as its usual consequence, atrophy of the elements of the parenchyma and hyperplasia of the stroma, followed by its compaction.. The same effect is obtained on the basis of partial starvation and chronic intoxications of both exo and endogenous origin.. This creates a premature hardening of the body, its premature senile withering.
The importance of occupational lead poisoning for the development of arthritism and gout, diseases that have long been attributed to hereditary constitutional metabolic disorders, is now well known. Data related to this can be found in any occupational health textbook..
They show with complete certainty that lead is a poison that selectively affects the elements of the mesenchyme no less than the nervous system, causing deep constitutional changes in the body..
On the other hand, the role of the individual characteristics of the organism in determining the constitutional increased susceptibility to intoxication is very large.. Negeli pays special attention, for example, to the need to change the profession of workers in a battery factory if, soon after starting work, at least weak symptoms of lead poisoning appear..
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