No one is surprised that physical education is useful for the heart, according to an online edition for girls and women from 14 to 35 years old Pannochka. net But there are cases when physical exercises can be harmful, and even deadly.

In the latest issue of the American Journal of Physiology - Heart and Circulatory Physiology, American scientists focused on precisely such situations.

Exercise reduces the risk of developing type 2 diabetes, hypertension, osteoporosis and even bowel cancer. In addition, a mobile lifestyle helps control blood pressure, body weight and "bad" cholesterol.

"The effect of physical exercises alone can be insignificant, but when combining an active lifestyle, eating well and healthy habits, you can achieve excellent results. But still, we want to better understand those situations where intense physical exercise can have serious consequences, "said Dr. Jeffrey Towbin, a member of the Children's Hospital of Cincinnati Medical Center.

Arrhythmogenic ventricular cardiomyopathy.

One such situation is arrhythmogenic ventricular cardiomyopathy. This is a rare disease that can cause sudden cardiac death right during exercise. Most scientists are concerned that this disease often occurs asymptomatically, until eventually it causes a cardiac arrest.

Arrhythmogenic ventricular cardiomyopathy is considered a genetic disease in which the structural integrity of the muscular wall of the heart is disturbed. The cells inside the heart muscle are bound by proteins called desmosomes. These desmosomes help to keep the wall intact and workable.

Desmosomes consist of several protein "bricks". In arrhythmogenic ventricular cardiomyopathy in one or more "bricks" there are defects, due to which the strength of the heart wall is violated. In this case, intense physical stress leads to the formation of a gap between the muscle cells. In these places, scar and fat tissue are formed, and the muscle becomes weaker and more vulnerable.

The role of desmoplakin.

Desmoplakin is a protein, one of the vital components of desmosomes.

Early experiments in mice with mutant forms of desmoplakin have shown that these animals develop symptoms reminiscent of arrhythmogenic ventricular cardiomyopathy.

In a recent study, Dr. Toubin's team studied the effects of exercise on mice with a mutant desmoplakin. Scientists have found that in such animals, intense physical activity rapidly worsens the condition of the heart muscle and contributes to the early onset of symptoms of the disease.

What is especially important, Dr. Toubin managed to find biomarkers of arrhythmogenic ventricular cardiomyopathy, which can be determined in the body long before the disease manifests itself. This can be of tremendous benefit in clinical practice, making it possible to identify vulnerable people and to limit them in time.

"Today, it is very difficult to detect changes in the heart muscle with this disease, since it does not have a characteristic handwriting. Rhythm disturbances and syncopal conditions, possible with arrhythmogenic ventricular cardiomyopathy, are observed in many other diseases. A new biomarker changes everything. Now we can diagnose a rare disease on time and save lives, "- explains the essence of his discovery, Dr. Tobin.

Wnt-beta-catenin.

The latest study brought another curious discovery. During the exercise, experimental mice showed significant disturbances in the biochemical chain of Wnt-beta-catenin.

Recall that this mechanism is responsible for the growth of new cells and stops the deposition of fat in the heart.

This can explain how the loads destroy the myocardium of patients. With such a small clue, scientists hope in the future not only to stop, but also reverse the development of arrhythmogenic ventricular cardiomyopathy.

In the meantime, it remains for such patients to control their workload and hope for the success of science.

medbe. en.

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