Inflammation serves as a natural protective mechanism of the body, which quickly copes with injuries or infections. However, with Alzheimer's disease, this protective reaction becomes chronic, which potentially exacerbates its course. A recent study told why the immune system of the brain in Alzheimer's disease reacts differently than bacterial infections, writes Newswise.
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At the upcoming 69th annual meeting of a biophysical society in Los Angeles, Dr. Arpan de de, a postdoxterant in the laboratory of Professor David Klenerman at the University of Cambridge, will present the results of the inflammation and disease of Alzheimer. In his study, the reaction of immune cells to the plaques of amyloid-Beta (AB) is a characteristic sign of Alzheimer's disease-and is compared with their reaction to bacterial toxins.
The doctor acts that although the hematoencephalic barrier does not allow bacteria to penetrate the brain, small proteins, such as AB, can imitate bacterial effects, potentially leading to neuro -sleeping and contributing to the development of dementia. The research group subjected immune cells the effects of AB and lipopolysaccharide units (LPS), a component of cell walls of bacteria, which causes a strong immune response.
Scientists focused on the formation of the Midos - the structures necessary to launch inflammation. Their observations showed that larger abogans caused the formation of meters in immune cells, while smaller abgars did not cause such a reaction even after prolonged exposure. This indicates that their size is crucial for the activation of the immune system during Alzheimer's disease.
On the contrary, the LPS caused a faster and stronger meta -bearing response than large AB units. Such a difference in the time and intensity of the reaction can explain why inflammation in Alzheimer's disease is protracted in nature, while the immune reaction to bacterial infections is usually fast and quickly passes. The doctor acts that the understanding of these differences in immune activation can be the key to the development of therapy aimed at chronic inflammation associated with Alzheimer's disease.
Researchers plan to study markers of Midos formation in human blood samples with dementia and brain samples from the British Bank of the brain. Adjusting into the mechanisms that cause inflammation during Alzheimer's disease, they strive to contribute to the development of treatment methods aimed at eliminating a chronic inflammatory reaction and potentially slowing down the progression of the disease.
This study not only deepens the understanding of scientists and doctors about the pathology of Alzheimer's disease, but also opens up new opportunities for the search for drugs from it. If we act on the paths involved in the immune response of the brain on AB units, you can develop therapy aimed at reducing chronic inflammation, which will give hope to people suffering from Alzheimer's disease and other neurodegenerative diseases, scientists believe.
Previously, Focus wrote about how to brush the teeth helps to identify Alzheimer's disease. Alzheimer's disease has a variety of symptoms, one of which is the withering of motor functions that can easily manifest itself in the most commonplace actions.
Focus also wrote that it is possible to deal with Alzheimer's disease with food. As the study showed, it is possible to significantly improve the condition of a person with Alzheimer's disease, if you change the approach to eating.
Important! This article is based on the latest scientific and medical research and does not contradict it. The text is exclusively informational in nature and does not contain medical advice. To establish a diagnosis, be sure to consult a doctor.