Researchers have long assumed that changes in the microbiom of the oral cavity-the accumulation of bacteria in the mouth can play a role in the development of squamous cell cancer of the oral cavity (SKRPR), but previous studies gave conflicting results regarding the bacterial picture with this disease. The new work tried to clarify these inconsistencies by analyzing the data of 11 previous studies and finally introduced more specifics to this theory, writes.
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Squamous cell cancer of the oral cavity is a life-threatening disease that occurs in cells lining the oral cavity, and is often diagnosed in the later stages, which complicates its treatment. According to the International Cancer Study Agency, about 450,000 people die annually from the SKRPR.
A research group led by Dr. Zhengjiang Zych from Southern Medical University in Shenzhen, China, revealed consistent bacterial patterns in saliva of people with SKRPR. The results of a study published in Msystems magazine confirmed that some bacteria, including Streptococcus, Lactobacillus and Prevotella, were more common among patients with SKRPR.
In addition, the study showed that the disease violates the normal structure of the microbioma associated with age and gender, which makes bacterial changes less predictable. Previous studies, in which samples of saliva of healthy people and patients with the SKRPR were compared, gave ambiguous results - some testified to an increase in microbial diversity, others - about its decrease.
The Xuya team eliminated this inconsistency by combining data, showing that with the SKRPR not only the level of individual bacteria changes, but also how these microbes interact with the human body. The study showed that these disorders can play a role in the progression of the disease, giving scientists an idea of \u200b\u200bits potential early signs.
Researchers took another step towards victory over the disease by training a machine learning model to detect microbial patterns associated with the SKRPR. When testing, the model accurately determined people with the SKRPR, and its accuracy increased as more data turned on. This suggests that in the future a screening tool based on saliva for the early detection of the SKRPR can be developed.
However, Suy warns that further research is needed to confirm the results in larger and various populations, before such a test can be used in clinical practice. The Xuya team plans to continue the study of bacterial patterns in different populations and track people with high risk over time.
The purpose of scientists is to understand why some people are more susceptible to the SKRPR and whether specific bacterial changes can serve as early indicators of the disease. If these patterns are confirmed in larger studies, saliva analysis can become a simple, non -invasive method of early detection of cancer, which will potentially increase survival indicators.
As scientists reveal more and more connections between the microbiota and our general health, the analysis of microorganisms can become the most important component of the future medical diagnosis of serious diseases in the early stages.
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Important! This article is based on the latest scientific and medical research and does not contradict it. The text is exclusively informational in nature and does not contain medical advice. To establish a diagnosis, be sure to consult a doctor.