Endocrinologist Gureeva Explains Why Being Overweight Leads to Diabetes. This explains why such a diet is a health risk factor, especially for diabetes..

In diabetes, the body is no longer able to break down sugar in the blood in sufficient quantities.. In a healthy body, the pancreas produces enough insulin to maintain a balanced blood sugar level.. In diabetics, the body can no longer do this..

Persistently high blood sugar damages the blood vessels and leads to consequences such as blindness or kidney failure.. It has long been known that overweight patients are particularly likely to develop type 2 diabetes and that adipose tissue plays a role in this..

" The reason is that the enzyme hexokinase 2, which normally ensures the breakdown of sugar in tissues, is no longer produced in sufficient quantities.. This causes the body to develop insulin resistance.. However, insulin is indispensable for transporting sugar from the blood to the cells and processing it there,"

Diabetes mellitus due to enzyme deficiency If hexokinase 2 is absent as a result of a high-fat diet, this limits not only the removal and breakdown of sugar in adipose tissue. Liver sugar metabolism is also out of balance. The liver produces more sugar than normal weight people with a balanced diet. Changes in adipose tissue and liver metabolism inevitably lead to permanently elevated blood sugar levels or diabetes.

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