Researchers at the University of Colorado School of Medicine found that blocking glycolysis and the CDK8 gene would cause malignant cancer cells to absorb much less glucose.. The latter is the main source of energy, which is necessary for tumor reproduction.. Without constant nourishment, the tumor becomes more susceptible to the effects of drugs..

Researchers note that cancers are characterized by the rapid consumption of huge amounts of carbohydrates.. In normal healthy cells, this glycolysis process proceeds very slowly, with the formation of pyruvate.. In infected cells, this process of glucose oxidation occurs more than 200 times faster, with the release of lactic acid..

Active absorption of sugars gives tumors a lot of energy, which allows them to quickly grow by multiplying cells and promote the development of metastases.. This phenomenon is called the "

Researchers attribute the reason for the use of large amounts of carbohydrates by cancer cells with an overexpression of the CDK8 gene.. It does not allow the tumor to experience a feeling of lack of blood glucose and oxygen.. American scientists managed to isolate this gene in cancer cells and thereby deprive them of the ability to accelerate the process of glycolysis..

Experts believe that the growth of malignant tumors can be combined with therapy that involves blocking the CDK8 gene and glycolysis. This will slow down the process of cancer development without affecting healthy cells, and will also make diseased cells more susceptible to drugs..

aspect. net.