An international team of scientists found that suppressing the activity of a specific C/EBP protein? -LIP delays aging in mice and extends animal lifespan.

As Lenta writes. ru, research preprint published in bioRxiv repository.

It is known that inhibition of the mTORC1 protein complex by rapamycin. mammalian target of rapamycin complex 1), which is involved in the regulation of protein synthesis, can prolong life in various animal species. In humans, however, this approach is difficult because downregulation of mTORC1 activity can cause unwanted side effects.. Therefore, researchers are looking for other ways through which it is possible to safely influence the work of the protein complex..

According to scientists, the transcription factor (gene activator) C / EBP can be a target for drugs.? This compound is involved in the metabolism of the liver and adipose tissues.. The gene responsible for the synthesis of this protein can also encode two isoforms of C/EBP? - Liver Activator Protein (LAP) and Liver-enriched Inhibitory Protein (LIP). The last compound is synthesized under the influence of mTORC1, which shifts the reading frame.

Reading frames are made up of sequences of triplet nucleotides, each of which encodes one specific amino acid.. Shifting the frame one nucleotide forward or backward changes the composition of the triplets and, consequently, the amino acid sequence in the corresponding protein..

With aging, the content of LIP in relation to LAP increases, however, scientists have shown that in mutant mice in which frameshift was suppressed, LIP in old age remains at a low level, and life expectancy is increased.. According to scientists, it is possible to inhibit the synthesis of Liver-enriched Inhibitory Protein in humans as well..

aspect. net.