A team of researchers representing several Canadian institutions has identified 15 tumor suppressor genes that can cause rapid growth of squamous cell carcinoma of the head and neck (HNSCC).

The group described CRISPR reverse genetic screening. They analyzed nearly five hundred genetic mutations leading to HNSCC.

This type of cancer is the sixth most common, alas, its survival is extremely low.. Scientists emphasize that there is a class of slowly mutating genes that can lead to tumors in a small number of patients.

Previous studies have shown that there are hundreds of so-called “long-tailed” genes, many of which have not been identified. In this new work, researchers used CRISPR reverse genetic screening, which allowed them to identify 15 of them..

Researchers screened CRISPR in vivo for 484 mutations of “long-tailed” genes that caused tumor development in mice and identified 15 suppressor genes.

Researchers concluded that 67 percent of human HNSCC cases are detected via Notch signaling.

https: // www. medikforum. com /.

Keywords:.