New clues to Alzheimer's disease Large-scale study of brain proteins reveals new information about Alzheimer's disease. Scientists analyzed the brains of people who died due to the progression of an insidious disease.

Emory University researchers have discovered new changes in the brains of people who have died from Alzheimer's that are directly linked to the disease.. Evidence highlights key role of proteins in insidious disease. Understanding these changes will help identify future therapeutic targets for developing new drugs for an as-yet untreatable disorder..

Forgetting to turn off the light? Dementia Coming in 12 Years Scientists have known for decades that most of the underlying damage to Alzheimer's disease is due to changes in brain proteins.. But in order to better understand what changes may occur in the brains of patients, scientists usually measure levels of ribonucleic acid, not proteins.. RNA is similar in shape to DNA, and often passes the genetic blueprints of proteins from cellular chromosomes to machinery that makes proteins..

Screening Study Offers New Data on Alzheimer's Because RNA is easier to work with, scientists have relied on it as a means of indirectly reading global changes in protein levels. Now, they've found that direct measurement of proteins on a large scale provides important clues to understanding Alzheimer's disease that can't be found by analyzing RNA alone.. Several protein networks have been identified that may be involved in the development of Alzheimer's disease, including protein communities that are up or down in a coordinated manner in people specifically with Alzheimer's disease..

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