According to a study published in the Journal of the American College of Cardiology, aspirin may not be useful for heart attacks and strokes in some people..

As part of the study, blood tests were taken and gene activity tests were carried out: resistance to aspirin was revealed due to its genetic influence on the cardiovascular system.

This work will be the next basis for future research that will reveal who benefits from aspirin use and who does not.. It also provides hints about the risks of individual patients associated with heart attacks..

Aspirin has been widely used as a cure for heart disease and stroke for over 50 years due to its ability to thin (reduce viscosity) the blood.. However, doctors still don't know exactly how aspirin works and why it doesn't work for all patients with heart disease..

Duke University Medical Center researchers analyzed two groups of healthy volunteers and one group with heart disease.. Patients in the latter group were treated with a low dose of aspirin.. Healthy volunteers were instructed to take 325 grams of aspirin each day for up to one month.. The researchers then observed the effects of aspirin on the regulation of gene expression and the function of platelets, the blood cells responsible for blood clotting..

After prescribing aspirin, doctors were able to identify the so-called " Its detection indicates an insufficient level of platelets as a reaction to aspirin therapy, both in patients and in healthy patients..

Geoffrey Ginsburg, director of genomic medicine at the Duke Institute: “We prescribe the same dose for all patients, but some patients may need a higher dose of aspirin or completely different treatments.. More effective tools are needed to monitor patients and adjust their treatment accordingly, as evidenced by the results of our study.”.

This is not the first study to measure levels of resistance to aspirin.. Another recent work, published in the American Heart Association's journal Circulation, aimed to test platelets from 400 healthy volunteers.. It was found that about one-third of the volunteers were resistant to the effects of aspirin in its daily use..

The signature of the body's response to aspirin, in addition to measuring the effectiveness of exposure to aspirin, can be used to predict the level of risk of heart attack in patients.

Deepak Voora, assistant professor at the Duke Institute and lead author of the study, explained: “There is something in the biology of platelets that determines how well we respond to aspirin, and with the help of a genomic signature in the blood, we need to determine this parameter.”.

Rochelle Long of the US National Institute of General Medical Sciences: "

This study could lead to a simple blood test that identifies patients who will not benefit from aspirin in this application, allowing them to choose other treatments.”.

medbe. en.