According to an observational study, boys who enter puberty at an early age are older than adult boys who develop later, regardless of their childhood weight, according to an observational study of more than 30,600 Swedish men born in.

In particular, the researchers found that boys who had a pubertal growth spurt between 9.3 and 13.4 years (the youngest group) were twice as likely to develop early type 2 diabetes (at age 57 or older).. net In addition to an increased risk of early type 2 diabetes, boys who went through puberty in the youngest group also had a 27% increased risk of late type 2 diabetes (after age 57), not as pronounced as early type 2 diabetes. The age of 57.2 years was the cut-off point for " The association between early puberty and early and late type 2 diabetes also persisted after adjusting for a number of factors, including year of birth, country of birth, birth weight, and education level..

Elevated BMI in adulthood is a well-known risk factor for type 2 diabetes.. Previous studies have shown that boys who are overweight during childhood or who are overweight during puberty are more likely to develop type 2 diabetes than adults.. In addition, available evidence suggests an association between early onset of puberty in girls (onset of menstruation) and a higher risk of developing diabetes, but retrospective studies in boys are hampered by the lack of readily available markers of puberty.. The aim of this new study was to determine whether the timing of puberty could be associated with the risk of developing diabetes in men, even after adjusting for changes in BMI, using an objective measure of time to puberty..

In this study, Associate Professor Jenny Kindbloom and Professor Claes Olsson of the University of Gothenburg, Sweden, and colleagues analyzed the medical records of 30,697 Swedish men born between 1945 and 1961, who measured BMI both in childhood (8 years) and. Adult life (age 20 years) in the epidemiological study of BMI Gothenburg - a population-based study in Sweden. Time to puberty was calculated from age at maximum growth rate (PHV), the time when boys grow fastest during the adolescent growth spurt, which occurs approximately 2 years after puberty.. The median age at puberty was 14 years.

Participant height and weight data in childhood and adolescence were linked to national registries and tracked until the end of 2016 or until they were diagnosed with type 2 diabetes, emigrated or died. During 30.7 years of follow-up (from age 30), 1851 men were diagnosed with type 2 diabetes, mean age 57.2 years.

For every year before the pubertal growth spurt, the risk of developing early diabetes increased by 28%, while the risk of late diabetes increased by 13%.. These associations were similar after adjusting for BMI at 8 years (24% vs 11%).

However, when the researchers adjusted the analysis of BMI after puberty (i.e., at age 20), the associations were attenuated and a significant association with late type 2 diabetes was lost.. Importantly, early puberty was still significantly associated with early type 2 diabetes, also after adjusting for BMI at 20 years, with a 16% increased risk of early diabetes in the year before puberty.. In contrast, a late puberty growth spurt (after age 15, the last 20%) was associated with a 30% lower risk of developing early diabetes (Table 5) compared to those who go through puberty in middle age (middle-20s)..

Men who had an early pubertal growth spurt were also more likely to need insulin treatment if they developed type 2 diabetes (25% increased risk of developing insulin-dependent type 2 diabetes for each year before puberty).

" “Given the apparent higher risk among boys who begin puberty before the median age of 14, we estimate that 15% fewer men diagnosed during the study would have developed type 2 diabetes if they had not started puberty..

She adds: “Although the mechanisms of association between early puberty and a higher risk of developing type 2 diabetes are unclear, it is possible that onset of puberty at an earlier age may lead to the accumulation of excess abdominal fat, which in turn increases cardiometabolic.

She concludes: “These data support the concept that early puberty is part of an unfavorable trajectory during childhood and adolescence, and that high BMI both before and after puberty contributes to. disease development. Continuous monitoring of height and weight gain, not only during childhood but also during adolescence, is essential and can help identify individuals at higher risk.”.

The authors acknowledge that their results show observational associations and do not prove that early puberty causes an increase in type 2 diabetes.. They note some limitations of the study, including not including data on BMI at older age or controls for family history of diabetes and smoking, both of which are known to increase the risk of developing diabetes.. They also indicate that the majority of participants were white, which could limit the generalizability of the results to other ethnic groups with a higher prevalence of type 2 diabetes..

medical-heal. en.