Hormone replacement therapy (HRT) in women undergoing hip arthroplasty reduces the incidence of complications after surgery. This is evidenced by the results of a large review study, according to the online publication for girls and women from 14 to 35 years old Pannochka. net During a 3-year period, women who used HRT for at least half a year after joint replacement were 40% less likely to need revision surgery (OR 0.62; 95% CI 0.41-0.94; P\u003d0.023).

In those women who continued HRT for at least a year, the risk of reoperation was reduced by more than half (OR 0.48; 95% CI 0.29-0.78; P\u003d0.003). These data were cited in the Annals of the Rheumatic Diseases by Dr. Nigel K. Arden, Research Fellow, University of Oxford.

Implant loss within 1 year after surgery was most commonly associated with chronic inflammation, near-joint osteolysis, and avascular necrosis.. The scientists noted: "

Some studies have previously explored the effects of antiresorptive agents such as bisphosphonates with their anti-osteoclastic properties, but results have been uncertain..

Hormone replacement therapy also has an antiresorptive effect on bones.. The British General Practice Research Database includes information on a large population of women who have used these agents in the past, as well as those who underwent knee and hip replacements from 1986 to 2006..

Of the 24,733 women who underwent joint replacements, the researchers selected 2,700 women who used HRT for at least 6 months after the procedure.. As a comparison group, 8,100 patients were selected, matching the rest of the criteria..

The average age of the participants was 65 years, body mass index 29. 56% of women had a hip replacement, the rest had a knee replacement. A total of 6% of patients were taking bisphosphonates, 1.4% were taking calcium and vitamin D, and 0.35% were taking corticosteroids..

The frequency of revision surgery in the group was 0.76% (95% CI 0.53-10.5) for the knee and 0.97% (95% CI 0.74-12.5) for the hip..

The revision rate in women using HRT for 6 months was 2.61 per 1,000 person-years (95% CI 1.79-3.61) compared to 4.25 (95% CI 3.81-5,.

After adding the possible effects of other drugs to the analysis, the researchers calculated that HRT gives an almost 40% reduction in the risk of revision (OR 0.61; 95% 0.41-0.92; P\u003d0.019).

At the same time, the use of HRT before surgery had no effect on the probability of unsuccessful joint transplantation (OR 1.06; 95% CI 0.66-1.70; P\u003d0.80). A possible explanation is the decrease in resorption associated with HRT, which is important after implantation..

Dr. Arden and colleagues recommended the use of antiresorptive agents after joint replacement for patients at increased risk of complications after surgery, while taking into account the risk of venous thromboembolism with HRT..

The results of the study may be limited by the survey nature of the work, as well as the presence of several unaccounted for factors - the type of implant, fixation, etc..

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