A group of scientists from the USA and Australia reported on the conduct of preclinical and first phase clinical trials of a new drug for coronavirus infection based on IgY immunoglobulin obtained from chicken eggs on the pages of medRxiv. org.
To achieve herd immunity, according to scientists, it is necessary that at least 70-80% of the world's population be vaccinated against the new coronavirus.. For various reasons, many citizens cannot receive the vaccine, thereby contributing to the spread of a dangerous pathogen.. The development of a nasal vaccine against coronavirus could be the very factor that can help solve the problem of achieving herd immunity, according to Pannochka, an online publication for girls and women from 14 to 35 years old.. net Keeping in mind that the nasal mucosa remains the main entry gate for the penetration of a new coronavirus infection into the human body, an international group of scientists decided to develop a drug, the introduction of which would be aimed at a direct effect on the nasal mucosa, which the virus uses to bind the spike protein to the receptor.
To obtain a sufficiently large number of antibodies that can be used in the creation of intranasal vaccines, the researchers used an unusual method.. First, they injected the receptor-binding domain of the SARS-CoV-2 spike protein into laying hens.. After 14-21 days, the eggs laid, vaccinated in this way by chickens, were found to contain a sufficiently high amount of protective antibodies against the new coronavirus..
Conducting tests of an intranasal vaccine with these antibodies with the participation of volunteers showed a fairly good tolerance of the developed drug, and a fairly low risk of developing severe immune reactions..
“Due to the fact that antibodies were able to provide reliable protection at the level of the nasal mucosa, we were able to avoid an increase in the levels of cytokines in the blood that cause the development of a systemic inflammatory immune response,” the researchers shared..
medical-heal. en.