New study finds green tea active ingredient impairs pancreatic cancer cell metabolism.

This not only provides an explanation for the fact that drinking green tea reduces the risk and slows the progression of cancer, but may also open up a new approach to the treatment of a deadly disease..

A study reported in the journal Metabolomics examined the effect of epigallocatechin gallate (EGCG), the active ingredient in green tea..

Scientists have shown that EGCG alters the metabolism of pancreatic cancer cells by suppressing the expression of lactate dehydrogenase A (LDHA), an enzyme very important for cell life..

Metabolism, or metabolism, is the totality of all chemical processes that occur in a cell, including the production and use of energy.. This is all that supports the life of the cell, its growth and ability to reproduce.. But the metabolism of normal and malignant cells is different, and it is these differences that scientists who are actively looking for new drugs against cancer can play on..

Previously, numerous studies suggested that green tea and its extracts could be an interesting alternative treatment for cancer, as well as other dangerous diseases..

For example, in 2012, scientists found that drinking green tea can reduce the likelihood of developing cancer of the gastrointestinal tract in women.. Another group of researchers went further - they tried to inject EGCG directly into the vessels of tumors, which led to "

EGCG disrupts metabolism by suppressing LDHA But until the results of the latest study by the team of Dr. Wai-Nang Lee of the Los Angeles Institute for Biomedical Research (LA BioMed), it was not clear how green tea and its extracts reduce cancer risk and slow growth..

Using the latest metabolic profiling technology, Dr. Lee's team discovered that one particular substance, epigallocatechin gallate, is responsible for disrupting the metabolic processes in pancreatic cancer cells..

They found that EGCG acts in the same way as oxamate, which is a known inhibitor of lactate dehydrogenase A..

A whole new way to look at metabolism Research plays a big role in the development of modern oncology, because it helps scientists to take a fresh look at the molecular mechanisms of cancer and exploit their weaknesses..

Commenting on the possibilities, Dr. Lee says: “By explaining how the active ingredient in green tea can prevent cancer, this study opened the door to a whole new area of \u200b\u200bcancer research and helped us understand how certain foods could be used to slow down cancer..

He says that this discovery allowed scientists to look at the metabolism of cancer cells in a new way: “Now we are no longer talking about primitive ideas that glucose enters the cell and provides energy.. Now we understand how specific metabolic pathways can be interrupted, and we know how this knowledge can be used to prevent and change the course of cancer.”.

In December 2013, Western publications reported that researchers at the University of Cambridge in the UK are working on a combination treatment that should force the immune system to actively fight pancreatic cancer.. A drug that breaks the protective membrane around pancreatic cancer cells, making it easy for T cells to attack and destroy them. This effect is greatly enhanced if the patient is given antibodies that increase the activity of T-cells..

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